CAJ | 학술논문

目的：观察单纯疱疹病毒性角膜炎（ Herpes simplex keratitis，HSK）合并白内障患者行白内障超声乳化术后视力变化及术后应用抗病毒药物预防单纯疱疹病毒性角膜炎复发的疗效。方法：单纯疱疹病毒性角膜炎合并白内障22例22眼行白内障超声乳化＋人工晶状体植入术，术后随机分为两组，治疗组给予口服阿昔洛韦及滴用更昔洛韦凝胶；对照组仅给予滴用更昔洛韦凝胶。观察术后视力变化情况；分析单纯疱疹病毒性角膜炎复发的情况。结果：术后6 mo随访，治疗组和对照组视力均获得提高；治疗组无1例出现单纯疱疹病毒性角膜炎的复发；对照组也仅有1例于术后6 mo复发，差异无显著性。结论：在抗病毒药物的保护下，＞6 mo未复发的单纯疱疹病毒性角膜炎不是白内障的手术禁忌，白内障手术能有效改善HSK合并白内障患者的视力；仅滴用更昔洛韦凝胶亦能有效预防白内障术后单纯疱疹病毒性角膜炎的复发。
목적：관찰단순포진병독성각막염（ Herpes simplex keratitis，HSK）합병백내장환자행백내장초성유화술후시력변화급술후응용항병독약물예방단순포진병독성각막염복발적료효。방법：단순포진병독성각막염합병백내장22례22안행백내장초성유화＋인공정상체식입술，술후수궤분위량조，치료조급여구복아석락위급적용경석락위응효；대조조부급여적용경석락위응효。관찰술후시력변화정황；분석단순포진병독성각막염복발적정황。결과：술후6 mo수방，치료조화대조조시력균획득제고；치료조무1례출현단순포진병독성각막염적복발；대조조야부유1례우술후6 mo복발，차이무현저성。결론：재항병독약물적보호하，＞6 mo미복발적단순포진병독성각막염불시백내장적수술금기，백내장수술능유효개선HSK합병백내장환자적시력；부적용경석락위응효역능유효예방백내장술후단순포진병독성각막염적복발。
AIM: To research the vision changes after phacoemulsification for herpes simplex keratitis ( HSK ) with cataract, and the clinical effect of antiviral drugs in preventing HSK relapse as well. METHODS:Twenty-two cases ( 22 eyes ) with HSK combined cataract were treated by phacoemulsification and intraocular lens implantation, and then randomly divided into two groups.The patients in treatment group received aciclovir tablets and ganciclovir ophthalmic gel, those in control group received ganciclovir ophthalmic gel only.The vision changes after phacoemulsification were observed and the HSK relapse was analyzed. RESULTS: After follow-up of 6 months, the visions of patients in both groups were improved. No relapse of HSK was found in the treatment group, and only one relapse of HSK was found in the control group after 6 months.There were no significant differences in therapy effects. CONCLUSION: Under the protection of antiviral drug, cataract surgery can be applied to patients with HSK recurrence-free more than 6 months, and improve the visions effectively. Ganciclovir ophthalmic gel can effectively prevent the relapse of HSK after cataract surgery.