国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2013年
11期
2240-2242
,共3页
异物%角膜%修复%重组人表皮生长因子
異物%角膜%脩複%重組人錶皮生長因子
이물%각막%수복%중조인표피생장인자
foreign body%cornea%repair%recombinant human epidermal growth factor
目的：探讨重组人表皮生长因子（ recombinant human epidermal growth factor ，rhEGF）对角膜异物剔除后角膜创面的修复效果。方法：选取2012-01/2013-01来我院就诊的角膜异物患者102例188眼为研究对象，根据随机数字表法分为治疗组和对照组。两组患者均于裂隙灯下剔除角膜异物，术后治疗组患眼应用重组人表皮生长因子衍生物滴眼液联合妥布霉素进行治疗，对照组患眼仅应用妥布霉素治疗。比较两组治疗3d后的疗效。结果：治疗后3d，治疗组的治愈率（93．7％）明显高于对照组治愈率（76．6％），差异具有统计学意义（P＜0．05）。治疗组荧光素染色阴性率为90．4％，高于对照组的46．8％，差异具有统计学意义（P＜0．01）。结论：rhEGF能够特异性和角膜上皮细胞受体结合，缩短损伤的角膜上皮的创伤愈合时间，加速愈合，是一种治疗外伤性角膜上皮缺损的有效方法。
目的：探討重組人錶皮生長因子（ recombinant human epidermal growth factor ，rhEGF）對角膜異物剔除後角膜創麵的脩複效果。方法：選取2012-01/2013-01來我院就診的角膜異物患者102例188眼為研究對象，根據隨機數字錶法分為治療組和對照組。兩組患者均于裂隙燈下剔除角膜異物，術後治療組患眼應用重組人錶皮生長因子衍生物滴眼液聯閤妥佈黴素進行治療，對照組患眼僅應用妥佈黴素治療。比較兩組治療3d後的療效。結果：治療後3d，治療組的治愈率（93．7％）明顯高于對照組治愈率（76．6％），差異具有統計學意義（P＜0．05）。治療組熒光素染色陰性率為90．4％，高于對照組的46．8％，差異具有統計學意義（P＜0．01）。結論：rhEGF能夠特異性和角膜上皮細胞受體結閤，縮短損傷的角膜上皮的創傷愈閤時間，加速愈閤，是一種治療外傷性角膜上皮缺損的有效方法。
목적：탐토중조인표피생장인자（ recombinant human epidermal growth factor ，rhEGF）대각막이물척제후각막창면적수복효과。방법：선취2012-01/2013-01래아원취진적각막이물환자102례188안위연구대상，근거수궤수자표법분위치료조화대조조。량조환자균우렬극등하척제각막이물，술후치료조환안응용중조인표피생장인자연생물적안액연합타포매소진행치료，대조조환안부응용타포매소치료。비교량조치료3d후적료효。결과：치료후3d，치료조적치유솔（93．7％）명현고우대조조치유솔（76．6％），차이구유통계학의의（P＜0．05）。치료조형광소염색음성솔위90．4％，고우대조조적46．8％，차이구유통계학의의（P＜0．01）。결론：rhEGF능구특이성화각막상피세포수체결합，축단손상적각막상피적창상유합시간，가속유합，시일충치료외상성각막상피결손적유효방법。
AIM: To investigate the repair efficacy of recombinant human epidermal growth factor on corneal epithelium after corneal foreign body eliminating operation. METHODS:There were 102 patients with corneal foreign body ( 188 affected eyes ) chosen for the study. All patients were divided into treatment group and control group according to the random number table. Both groups received corneal foreign body elimination by slit lamp.Postoperatively, the treatment group was given eye drops containing epidermal growth factor ( JinYinShu) combined with tobramycin while the control group was only administrated with tobramycin. Treatment effects were compared 3d after treatment. RESULTS: Three days after treatment, the cure rate in the treatment group ( 93.7%), was significantly higher than that in the control group (76.6%) (P<0.05).In the treatment group, fluorescein staining was negative in 90.4%of the cases, significantly higher than that in the control group (46.8%) (P<0.01). CONCLUSION: The recombinant human epidermal growth factor is capable of integrating with corneal epithelial cells and endothelial cell receptor, shortening healing time of corneal epithelial wound, thus making it an effective treatment of traumatic corneal epithelial defect.
