CAJ | 학술논문

目的：探讨检测血浆中D-二聚体（ D-D）、纤维蛋白原（ Fib）及其降解产物（ FDP）的水平在眼恶性肿瘤诊断和病情评估方面的应用及临床意义。方法：选择我院眼科确诊为眼恶性肿瘤患者67例（恶性肿瘤组），其中眼恶性肿瘤无转移组（44例）、眼恶性肿瘤转移组（23例）；同期收治的眼良性肿瘤患者46例（良性肿瘤组）；本院同期健康体检者30例（健康对照组）。测定血浆中D-D、Fib、FDP水平并进行比较。结果：眼恶性肿瘤患者血浆中D-D、Fib、FDP水平显著高于眼良性肿瘤组、健康对照组（P＜0．05），其中恶性肿瘤转移组患者血浆中D-D、Fib、FDP水平又显著高于恶性肿瘤无转移组（P＜0．05）。而眼良性肿瘤与健康对照组血浆中D-D、Fib、FDP水平差异无统计学意义（P＞0．05）。各组D-D含量分布差异有统计学意义（P＜0．05）。结论：血浆中D-D、Fib、FDP水平的检测对于眼良恶性肿瘤的判断及肿瘤的进展及预后有重要的临床意义。
목적：탐토검측혈장중D-이취체（ D-D）、섬유단백원（ Fib）급기강해산물（ FDP）적수평재안악성종류진단화병정평고방면적응용급림상의의。방법：선택아원안과학진위안악성종류환자67례（악성종류조），기중안악성종류무전이조（44례）、안악성종류전이조（23례）；동기수치적안량성종류환자46례（량성종류조）；본원동기건강체검자30례（건강대조조）。측정혈장중D-D、Fib、FDP수평병진행비교。결과：안악성종류환자혈장중D-D、Fib、FDP수평현저고우안량성종류조、건강대조조（P＜0．05），기중악성종류전이조환자혈장중D-D、Fib、FDP수평우현저고우악성종류무전이조（P＜0．05）。이안량성종류여건강대조조혈장중D-D、Fib、FDP수평차이무통계학의의（P＞0．05）。각조D-D함량분포차이유통계학의의（P＜0．05）。결론：혈장중D-D、Fib、FDP수평적검측대우안량악성종류적판단급종류적진전급예후유중요적림상의의。
AIM:To explore the meaning of the level of D-dimer ( D-D), fibrinogen ( Fib ) and fibrin degradation products ( FDP) in serum for eye malignant tumor diagnosis and evaluation. METHODS: Sixty-seven patients with eye malignant tumor ( malignant tumor group ) in our hospital were selected, among which, 44 as malignant tumor without metastasis group, 23 as malignant tumor with metastasis group; 46 patients were selected with eye benign tumor (benign tumor group) during the same time period; 30 healthy people visited our hospital for regular physical examination was elected simultaneously as the healthy control group. The level of D-D, Fib and FDP were detected in serum. RESULTS:The D-D, Fib and FDP level in eye malignant tumor group was significantly higher than those in either the eye benign tumor group or the healthy control group (P<0.01), malignant tumor with metastasis group had the significant higher level of D-D, Fib and FDP than those of malignant tumor without metastasis group ( P<0.05 ) . There was no significant difference statistically between the eye benign tumor group and healthy control group of the serum level of D-D, Fib and FDP (P>0.05). There was significant difference of D-D level distribution among each group (P<0.05). CONCLUSION:To detect the level of D-D, Fib and FDP in serum can help with differentiation the tumor from benign to malignancy, analysis the progression of tumor and prognosis.