CAJ | 학술논문

分别采用乙醇、甲醛、甲酸钠、硼氢化钠为还原剂，聚乙烯吡咯烷酮（PVP）为稳定剂，制备了负载型PVP-Pt/γ-Al2O3催化剂，考察了催化剂对2-氧-4-苯基丁酸乙酯不对称加氢合成(R)-2-羟基-4-苯基丁酸乙酯的性能，其中硼氢化钠作为还原剂时性能最佳。研究了制备条件如还原温度、还原浓度、还原介质、PVP/Pt 物质的量比以及反应溶剂、时间等因素对催化结果的影响。实验结果表明，在 PVP/Pt=5∶1、还原温度0℃、NaBH4浓度为0.5 mol/L、乙醇作为还原介质制备的催化剂，对2-氧-4-苯基丁酸乙酯（EOPB）不对称加氢的转化率可达100%，对映选择性为76.8%e.e.。
분별채용을순、갑철、갑산납、붕경화납위환원제，취을희필각완동（PVP）위은정제，제비료부재형PVP-Pt/γ-Al2O3최화제，고찰료최화제대2-양-4-분기정산을지불대칭가경합성(R)-2-간기-4-분기정산을지적성능，기중붕경화납작위환원제시성능최가。연구료제비조건여환원온도、환원농도、환원개질、PVP/Pt 물질적량비이급반응용제、시간등인소대최화결과적영향。실험결과표명，재 PVP/Pt=5∶1、환원온도0℃、NaBH4농도위0.5 mol/L、을순작위환원개질제비적최화제，대2-양-4-분기정산을지（EOPB）불대칭가경적전화솔가체100%，대영선택성위76.8%e.e.。
A series of catalysts PVP-Pt/γ-Al2O3 were prepared by different reduction methods (ethanol, HCHO,HCOONa,and NaBH4) in the presence of PVP (polyvinylpyrrolidone) as stabilizer,the catalytic performance for asymmetric hydrogenation of ethyl 2-oxo-4-phenylbutyrate to ethyl (R)-2-hydroxy-4-phenylbutyrate was tested.The catalyst prepared by using NaBH4 as reducing agent showed the best overall performance.The effect of various catalyst preparation conditions,such as reduction temperature,NaBH4 concentration,the medium in which reduction was carried out, PVP/Pt mole ratio and reaction solvent and time,was also investigated. Ethyl (R)-2-hydroxy-4-phenylbutyrate could be obtained with 100%yield and 76.8%e.e. when catalyst was prepared at 0 ℃ using 0.5 mol/L NaBH4 in a medium of ethanol.