CAJ | 학술논문

目的探讨强直性脊柱炎(ankylosing spondylitis，AS)患者血清IL-21、IL-6的变化及临床意义。方法应用酶联免疫吸附试验(ELISA)测定50例AS患者（分AS病情活动组30例、稳定组20例）和30例正常对照者血清中IL-21及IL-6水平，并进行比较。结果 AS患者活动期IL-21及IL-6水平明显高于正常组，差异有统计学意义(<0.01)，稳定期IL-21及IL-6水平与活动期比较明显降低（约0.05），但仍高于正常对照组（约0.05）。结论 IL-21和IL-6可能协同参与了AS的发病过程，其水平高低随病情轻重、病程而变化；临床上对AS患者应定期观察其血清中IL-21、IL-6水平变化，以判断治疗效果及其预后。
목적탐토강직성척주염(ankylosing spondylitis，AS)환자혈청IL-21、IL-6적변화급림상의의。방법응용매련면역흡부시험(ELISA)측정50례AS환자（분AS병정활동조30례、은정조20례）화30례정상대조자혈청중IL-21급IL-6수평，병진행비교。결과 AS환자활동기IL-21급IL-6수평명현고우정상조，차이유통계학의의(<0.01)，은정기IL-21급IL-6수평여활동기비교명현강저（약0.05），단잉고우정상대조조（약0.05）。결론 IL-21화IL-6가능협동삼여료AS적발병과정，기수평고저수병정경중、병정이변화；림상상대AS환자응정기관찰기혈청중IL-21、IL-6수평변화，이판단치료효과급기예후。
Objective To discussion serum IL-21, IL-6 changes and clinical significance in ankylosing spondylitis (ankylosing spondylitis, AS)patients. Methods Enzyme-linked immunosorbent assay (ELISA) was applied to measure serum IL-21 and IL-6 levels, include 50 AS patients (disease activity of 30 patients, 20 patients stable) and 30 normal controls.Results IL-21 and IL-6 levels in AS patients in active phase were significantly higher than the normal group, and the dif erence was statistical y significant ( <0.01). IL-21 and IL-6 levels in stable phase were significantly lower than those in active period ( <0.05), but which were higher than the normal control group ( <0.05).Conclusion IL-21 and IL-6 may be involved in the pathogenesis of AS, which change along with the disease of severity, duration; TO observed IL-21, IL-6 serum levels regularly in AS patients in clinic was helpful for treatment and prognosis.