中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
13期
5993-5997
,共5页
蒋俊%权循凤%张丽%汪义纯
蔣俊%權循鳳%張麗%汪義純
장준%권순봉%장려%왕의순
食管肿瘤%放射疗法%Meta分析%甘氨双唑钠
食管腫瘤%放射療法%Meta分析%甘氨雙唑鈉
식관종류%방사요법%Meta분석%감안쌍서납
Esophageal neoplasms%Radiotherapy%Meta-analysis%Sodium glycididazole
目的：运用Meta分析的方法系统评价甘氨双唑钠对食管鳞癌放疗增敏的疗效及安全性。方法搜索Cochrane Library、Pubmed、Embase、CBM、CNKI、万方及维普数据库系统，收集有关放疗联合甘氨双唑钠与单纯放疗治疗食管鳞癌的随机对照研究（ RCT）。采用STATA 12.0软件对相关数据进行Meta分析。结果本研究共纳入10篇RCT，总计776例患者。 Meta分析结果显示：放疗联合甘氨双唑钠增敏治疗组与单纯放疗组相比，近期疗效前者高于后者（ OR＝3.945，95％CI＝2.495～6.239；P＝0.000）；远期疗效两组相近（1年生存率：OR＝1.487，95％ CI＝0.816～2.711；P＝0.195；2年生存率：OR＝1.413，95％ CI＝0.680～2.937；P＝0.354）；不良反应发生率两组的差异无统计学意义（消化道反应：OR＝0.682，95％ CI＝0.063～7.414；P＝0.753；血液学毒性：OR＝1.228，95％CI＝0.520～2.899；P＝0.640）。结论现有研究表明，放疗联合甘氨双唑钠增敏治疗较单纯放疗能进一步提高食管鳞癌患者的近期疗效，无明显不良反应的发生，安全性好，远期疗效的评价有待更多高质量的随机对照研究。
目的：運用Meta分析的方法繫統評價甘氨雙唑鈉對食管鱗癌放療增敏的療效及安全性。方法搜索Cochrane Library、Pubmed、Embase、CBM、CNKI、萬方及維普數據庫繫統，收集有關放療聯閤甘氨雙唑鈉與單純放療治療食管鱗癌的隨機對照研究（ RCT）。採用STATA 12.0軟件對相關數據進行Meta分析。結果本研究共納入10篇RCT，總計776例患者。 Meta分析結果顯示：放療聯閤甘氨雙唑鈉增敏治療組與單純放療組相比，近期療效前者高于後者（ OR＝3.945，95％CI＝2.495～6.239；P＝0.000）；遠期療效兩組相近（1年生存率：OR＝1.487，95％ CI＝0.816～2.711；P＝0.195；2年生存率：OR＝1.413，95％ CI＝0.680～2.937；P＝0.354）；不良反應髮生率兩組的差異無統計學意義（消化道反應：OR＝0.682，95％ CI＝0.063～7.414；P＝0.753；血液學毒性：OR＝1.228，95％CI＝0.520～2.899；P＝0.640）。結論現有研究錶明，放療聯閤甘氨雙唑鈉增敏治療較單純放療能進一步提高食管鱗癌患者的近期療效，無明顯不良反應的髮生，安全性好，遠期療效的評價有待更多高質量的隨機對照研究。
목적：운용Meta분석적방법계통평개감안쌍서납대식관린암방료증민적료효급안전성。방법수색Cochrane Library、Pubmed、Embase、CBM、CNKI、만방급유보수거고계통，수집유관방료연합감안쌍서납여단순방료치료식관린암적수궤대조연구（ RCT）。채용STATA 12.0연건대상관수거진행Meta분석。결과본연구공납입10편RCT，총계776례환자。 Meta분석결과현시：방료연합감안쌍서납증민치료조여단순방료조상비，근기료효전자고우후자（ OR＝3.945，95％CI＝2.495～6.239；P＝0.000）；원기료효량조상근（1년생존솔：OR＝1.487，95％ CI＝0.816～2.711；P＝0.195；2년생존솔：OR＝1.413，95％ CI＝0.680～2.937；P＝0.354）；불량반응발생솔량조적차이무통계학의의（소화도반응：OR＝0.682，95％ CI＝0.063～7.414；P＝0.753；혈액학독성：OR＝1.228，95％CI＝0.520～2.899；P＝0.640）。결론현유연구표명，방료연합감안쌍서납증민치료교단순방료능진일보제고식관린암환자적근기료효，무명현불량반응적발생，안전성호，원기료효적평개유대경다고질량적수궤대조연구。
Objective To assess the efficacy and safety of radiotherapy combined with sodium glycididazole in treating esophageal squamous carcinoma by conducting a meta-analysis.Methods A comprehensive collection of randomized controlled studies ( RCTs ) of radiotherapy plus sodium glycididazole versus radiotherapy alone in the treatment of esophageal squamous carcinoma , that was retrieved form Cochrane Library , Pubmed, Embase, CBM, CNKI,Wanfang and VIP databases .Meta-analysis was conducted by STATA 12.0 software.Results Ten RCTs involving 776 patients were identified in the study .The Meta analysis results showed that:radiotherapy combined with sodium glycididazole group had a better short-term effect than single radiotherapy group ( OR=3.945,95% CI=2.495-6.239;P=0.000 ) .The long-term effect of the two groups were similar ( one year survival rate:OR=1.487 , 95%CI=0.816-2.711;P=0.195;two year survival rate:OR=1.413 ,95% CI=0.680-2.937;P=0.354 ) .The incidence rate of adverse reaction of heating in the former was higher than that in the latter ( RR=3.56 ,95% CI=2.28-5.56;P <0.000 01 );There were no significant difference in the incidence rate of adverse reaction ( gastrointestinal reaction:OR=0.682 ,95%CI=0.063-7.414;P=0.753;hematological toxicity:OR=1.228 ,95%CI=0.520-2.899;P=0.640).Conclusion The study shows that,the short-term effect of radiotherapy combined with sodium glycididazole for the treatment of esophageal squamous carcinoma is superior to radiotherapy alone . Meanwhile ,no significant adverse reactions occur and the safety is identified .More high quality randomized controlled studies are expected for the evaluation of the long-term effect.
