中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
13期
5790-5793
,共4页
张洁%赵兴胜%景兰%史萌萌
張潔%趙興勝%景蘭%史萌萌
장길%조흥성%경란%사맹맹
抑郁症%高血压%甲状腺激素类
抑鬱癥%高血壓%甲狀腺激素類
억욱증%고혈압%갑상선격소류
Depressive disorder%Hypertension%Thyroid hormones
目的：探讨高血压病合并抑郁症患者血清甲状腺激素水平的变化。方法采用化学发光法分别测定高血压病合并抑郁症组（n＝50）、高血压病组（n＝50）、抑郁症组（n＝50）、健康对照组（n＝50）的血清甲状腺激素FT3、FT4、TSH水平并进行比较。结果高血压病合并抑郁症组的FT3浓度明显低于高血压病组、抑郁症组和健康对照组（ P＝0.036， P＝0.041， P＝0.000）。四组中低T3综合征的发生率分别为：35.0％、22.0％、12.0％、4.0％，且差异有显著性（χ2＝10.821， P＝0.010）。高血压病合并抑郁症组的血清FT3浓度与高血压病分级、汉密顿（HAMD）量表总分均呈负相关（P＝0.000，P＝0.013）。控制HAMD量表总分时，其FT3浓度与高血压病分级的偏相关系数为-0.584，P＝0.000。控制高血压病分级时，其FT3浓度与HAMD量表总分的偏相关系数为-0.365，P＝0.044。结论高血压病合并抑郁症患者的血清FT3浓度明显下降，更易发生低T3综合征，且其FT3浓度与高血压病分级、HAMD量表总分之间均存在负相关关系，FT3水平可以作为判断高血压病合并抑郁症患者病情严重程度的指标之一，对判断预后及指导治疗具有重要意义。
目的：探討高血壓病閤併抑鬱癥患者血清甲狀腺激素水平的變化。方法採用化學髮光法分彆測定高血壓病閤併抑鬱癥組（n＝50）、高血壓病組（n＝50）、抑鬱癥組（n＝50）、健康對照組（n＝50）的血清甲狀腺激素FT3、FT4、TSH水平併進行比較。結果高血壓病閤併抑鬱癥組的FT3濃度明顯低于高血壓病組、抑鬱癥組和健康對照組（ P＝0.036， P＝0.041， P＝0.000）。四組中低T3綜閤徵的髮生率分彆為：35.0％、22.0％、12.0％、4.0％，且差異有顯著性（χ2＝10.821， P＝0.010）。高血壓病閤併抑鬱癥組的血清FT3濃度與高血壓病分級、漢密頓（HAMD）量錶總分均呈負相關（P＝0.000，P＝0.013）。控製HAMD量錶總分時，其FT3濃度與高血壓病分級的偏相關繫數為-0.584，P＝0.000。控製高血壓病分級時，其FT3濃度與HAMD量錶總分的偏相關繫數為-0.365，P＝0.044。結論高血壓病閤併抑鬱癥患者的血清FT3濃度明顯下降，更易髮生低T3綜閤徵，且其FT3濃度與高血壓病分級、HAMD量錶總分之間均存在負相關關繫，FT3水平可以作為判斷高血壓病閤併抑鬱癥患者病情嚴重程度的指標之一，對判斷預後及指導治療具有重要意義。
목적：탐토고혈압병합병억욱증환자혈청갑상선격소수평적변화。방법채용화학발광법분별측정고혈압병합병억욱증조（n＝50）、고혈압병조（n＝50）、억욱증조（n＝50）、건강대조조（n＝50）적혈청갑상선격소FT3、FT4、TSH수평병진행비교。결과고혈압병합병억욱증조적FT3농도명현저우고혈압병조、억욱증조화건강대조조（ P＝0.036， P＝0.041， P＝0.000）。사조중저T3종합정적발생솔분별위：35.0％、22.0％、12.0％、4.0％，차차이유현저성（χ2＝10.821， P＝0.010）。고혈압병합병억욱증조적혈청FT3농도여고혈압병분급、한밀돈（HAMD）량표총분균정부상관（P＝0.000，P＝0.013）。공제HAMD량표총분시，기FT3농도여고혈압병분급적편상관계수위-0.584，P＝0.000。공제고혈압병분급시，기FT3농도여HAMD량표총분적편상관계수위-0.365，P＝0.044。결론고혈압병합병억욱증환자적혈청FT3농도명현하강，경역발생저T3종합정，차기FT3농도여고혈압병분급、HAMD량표총분지간균존재부상관관계，FT3수평가이작위판단고혈압병합병억욱증환자병정엄중정도적지표지일，대판단예후급지도치료구유중요의의。
Objective To study the alteration of serum thyroid hormone FT 3, FT4, TSH in hypertension patients with depression .Methods The serum FT3, FT4, TSH levels were measured with chemiluminescence in hypertension patients with depression group (n=50),hypertension group(n=50),patients with depression(n=50), healthy control group ( n=50 ) and then compared .Results The serum FT3 concentrations of hypertension patients with depression group were significantly lower than the other three groups ( P=0.036 , P=0.041 , P=0.000 ) .Its serum FT4 concentrations were significantly lower than the healthy control group ( P=0.028 ) .The incidence rate of low T3 syndrome in four groups respectively were 35.0%,22.0%,12.0%,4.0% and difference between them was significant (χ2 =10.821 , P=0.010 ) .There was a negative correlation between the serum FT 3 concentrations of hypertension with depression group and hypertension grade , Hamilton depression scale ( HAMD ) total score ( P =0.000,P=0.013).Control the HAMD total score,the partial correlation coefficient of the FT3 concentrations and hypertension grade was -0.584,P=0.000.Control the hypertension grade ,the partial correlation coefficient of the FT3 concentrations and the HAMD total score was -0.365 ,P=0.044 .Conclusion The serum FT3 concentrations of hypertension patients with depression were significantly decreased and had a higher prevalence of low T 3 syndrome.There was a negative correlation between the serum FT 3 concentrations and hypertension grade ,HAMD score.The level of FT3,as one of the indicators of evaluating the severity of hypertension patients with depression ,had a great significance to determine the prognosis and guide the treatment .
