中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
7期
46-47
,共2页
帕金森病%精神障碍%喹硫平
帕金森病%精神障礙%喹硫平
파금삼병%정신장애%규류평
Parkinson's disease%Mental disorders%Quetiapine
目的：探讨喹硫平治疗帕金森病(PD)并发精神障碍的疗效及不良反应。方法收集帕金森病合并精神障碍患者100例，治疗组50例，对照组50例，对照组调整抗帕金森药物治疗，治疗组在此基础之上加用喹硫平治疗，观察6周，治疗前后采用UPDRS评定运动功能，精神症状阳性症状量表(SAPS)评价患者精神症状程度，以SAPS减分率评定疗效。结果两组SAPS量表评价比较，幻觉和妄想二项精神症状评分差异有统计学意义评分，治疗组患者治疗前后运动障碍差异无统计学意义，对照组运动障碍有统计学意义。结论喹硫平对PD并发幻觉妄想等阳性精神症状的患者疗效肯定安全，且不加重运动障碍。
目的：探討喹硫平治療帕金森病(PD)併髮精神障礙的療效及不良反應。方法收集帕金森病閤併精神障礙患者100例，治療組50例，對照組50例，對照組調整抗帕金森藥物治療，治療組在此基礎之上加用喹硫平治療，觀察6週，治療前後採用UPDRS評定運動功能，精神癥狀暘性癥狀量錶(SAPS)評價患者精神癥狀程度，以SAPS減分率評定療效。結果兩組SAPS量錶評價比較，幻覺和妄想二項精神癥狀評分差異有統計學意義評分，治療組患者治療前後運動障礙差異無統計學意義，對照組運動障礙有統計學意義。結論喹硫平對PD併髮幻覺妄想等暘性精神癥狀的患者療效肯定安全，且不加重運動障礙。
목적：탐토규류평치료파금삼병(PD)병발정신장애적료효급불량반응。방법수집파금삼병합병정신장애환자100례，치료조50례，대조조50례，대조조조정항파금삼약물치료，치료조재차기출지상가용규류평치료，관찰6주，치료전후채용UPDRS평정운동공능，정신증상양성증상량표(SAPS)평개환자정신증상정도，이SAPS감분솔평정료효。결과량조SAPS량표평개비교，환각화망상이항정신증상평분차이유통계학의의평분，치료조환자치료전후운동장애차이무통계학의의，대조조운동장애유통계학의의。결론규류평대PD병발환각망상등양성정신증상적환자료효긍정안전，차불가중운동장애。
Objective To investigate the effect of quetiapine, in the treatment of mental disorders in parkinson' s disease (PD). Methods 100 patients with mental disorders in parkinson's disease were randomly assigned quetiapine, group and controls group. UPDRS, SAPS scales were tested before treatment and after 6 weeks’ treatment in order to observe symptoms including hallucinosis, deliria and abnormal behavior and dyskinesia. Results Compare with controls group, hallucinosis, deliria and abnormal behavior in quetiapine, group were signiifcant improved (P<0.05). Conclusion Quetiapine appears to an effective drug for PD patients with mental disorders, quetiapine is safe for those patients.
