中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
7期
26-27
,共2页
王开俊%胡先平%任俏%黄龙%邓世辉
王開俊%鬍先平%任俏%黃龍%鄧世輝
왕개준%호선평%임초%황룡%산세휘
靶控输注%微泵输注%丙泊酚%双气囊小肠镜
靶控輸註%微泵輸註%丙泊酚%雙氣囊小腸鏡
파공수주%미빙수주%병박분%쌍기낭소장경
Target-controlled infusion%Micro pump infusion%Propofol%Double-balloon enteroscopy
目的：观察靶控输注与微泵输注丙泊酚用于双气囊小肠镜检查的效果和安全性。方法40例ASAⅠ~Ⅱ级拟行双气囊小肠镜检查的患者，年龄22~60岁，体质量45~70kg，随机分为靶控组（TCI泵）和微泵组（恒速微泵），每组20例。分别采用靶控输注和微泵输注两种方式输注丙泊酚。靶控组以血浆药物浓度为靶目标进行靶控输注丙泊酚，靶浓度为2.5~4μg/mL。微泵组以丙泊酚4~8mg/(kg?h)恒速输注。两组术中均视体动、呛咳反应调整输出血浆靶浓度。记录患者给药前（T0）、给药后1min（T1）、给药后5min（T2）术中1h（T3）和苏醒时（T4）的HR、MAP、RR、SpO2的变化；观察诱导时间、苏醒时间、镜检时间、丙泊酚总用量、不良反应发生率及满意度。结果所有患者均能完成操作，微泵组给药后1min（T1）MAP、HR、RR较给药前（T0）下降（P＜0.05），靶控组MAP、HR、RR下降轻，两组比较有统计学意义（P＜0.05）。给药后5min（T2）术中1h（T3）和苏醒时（T4）两组的HR、MAP、RR比较无统计学意义（P＞0.05）。两组SpO2、诱导、苏醒时间、镜检时间及满意度无统计学意义（P＞0.05）。靶控组丙泊酚总用量及不良反应发生率少于微泵组（P＜0.05）。结论靶控输注丙泊酚麻醉诱导平稳，术中麻醉效果好，可减少丙泊酚的用量和不良反应。
目的：觀察靶控輸註與微泵輸註丙泊酚用于雙氣囊小腸鏡檢查的效果和安全性。方法40例ASAⅠ~Ⅱ級擬行雙氣囊小腸鏡檢查的患者，年齡22~60歲，體質量45~70kg，隨機分為靶控組（TCI泵）和微泵組（恆速微泵），每組20例。分彆採用靶控輸註和微泵輸註兩種方式輸註丙泊酚。靶控組以血漿藥物濃度為靶目標進行靶控輸註丙泊酚，靶濃度為2.5~4μg/mL。微泵組以丙泊酚4~8mg/(kg?h)恆速輸註。兩組術中均視體動、嗆咳反應調整輸齣血漿靶濃度。記錄患者給藥前（T0）、給藥後1min（T1）、給藥後5min（T2）術中1h（T3）和囌醒時（T4）的HR、MAP、RR、SpO2的變化；觀察誘導時間、囌醒時間、鏡檢時間、丙泊酚總用量、不良反應髮生率及滿意度。結果所有患者均能完成操作，微泵組給藥後1min（T1）MAP、HR、RR較給藥前（T0）下降（P＜0.05），靶控組MAP、HR、RR下降輕，兩組比較有統計學意義（P＜0.05）。給藥後5min（T2）術中1h（T3）和囌醒時（T4）兩組的HR、MAP、RR比較無統計學意義（P＞0.05）。兩組SpO2、誘導、囌醒時間、鏡檢時間及滿意度無統計學意義（P＞0.05）。靶控組丙泊酚總用量及不良反應髮生率少于微泵組（P＜0.05）。結論靶控輸註丙泊酚痳醉誘導平穩，術中痳醉效果好，可減少丙泊酚的用量和不良反應。
목적：관찰파공수주여미빙수주병박분용우쌍기낭소장경검사적효과화안전성。방법40례ASAⅠ~Ⅱ급의행쌍기낭소장경검사적환자，년령22~60세，체질량45~70kg，수궤분위파공조（TCI빙）화미빙조（항속미빙），매조20례。분별채용파공수주화미빙수주량충방식수주병박분。파공조이혈장약물농도위파목표진행파공수주병박분，파농도위2.5~4μg/mL。미빙조이병박분4~8mg/(kg?h)항속수주。량조술중균시체동、창해반응조정수출혈장파농도。기록환자급약전（T0）、급약후1min（T1）、급약후5min（T2）술중1h（T3）화소성시（T4）적HR、MAP、RR、SpO2적변화；관찰유도시간、소성시간、경검시간、병박분총용량、불량반응발생솔급만의도。결과소유환자균능완성조작，미빙조급약후1min（T1）MAP、HR、RR교급약전（T0）하강（P＜0.05），파공조MAP、HR、RR하강경，량조비교유통계학의의（P＜0.05）。급약후5min（T2）술중1h（T3）화소성시（T4）량조적HR、MAP、RR비교무통계학의의（P＞0.05）。량조SpO2、유도、소성시간、경검시간급만의도무통계학의의（P＞0.05）。파공조병박분총용량급불량반응발생솔소우미빙조（P＜0.05）。결론파공수주병박분마취유도평은，술중마취효과호，가감소병박분적용량화불량반응。
Objective Observation the efifcacy and safety use micro-target-controlled infusion of propfol and infusion pump for double-balloon enteroscopy. Methods 40 cases of ASA Ⅰ-Ⅱ patients who undergo double-ballon enter oscopy. 22-60 years and weight 45-70 kg were divided into target-contrubed group (TCI pump) and micro-pump (DA-speed micro-pump) randomly and 20 patients in each group. Which were used to target controlled infusion pumps and micro-infusion of propofol in two ways. Target controlled group infusion of propfol with plasma drug concentration in target, target concentration 2.5-4 μg/mL micro-pump group constant infusion of propofol 4-8 mg/(kg?h) both groups were treated in body movement, cough reaction to adjust the output target plasma concentration. Recording before administration (T0), after administration of 1 min (T1), after treatment 5min (T2), intraoperative 1h (T3) and awakening (T4) of HR, MAP, RR, SpO2; observed induction time, recovery time. Microscopic examination time, total propofol dosage, adverse reaction rates and satisfaction.Results All patients could complete the operation. Micro-pump after administration 1 min (T1) compared with before administration (T0), MAP, HR, RR were decreased (P<0.05), after administration 5 min (T2) intraoperative 1 h (T3) and awaking (T4) in both groups HR, MAP, RR were not statistically signiifcant (P>0.05). Two group’s SpO2, induction and recovery time, microscopic examination time and satisfaction were not statistically (P>0.05). Propofol dosage and the total incidence of adverse reactions of target-controlled group less than micro-pump group (P>0.05). Conclusion Target-controudd infusion of propofol induction of anesthesia smooth, anesthetic effete is good which can reduce the amount of propofol and adverse reactions.
