CAJ | 학술논문

目的：应用24h动态血压监测（24hABPM）分析江苏省省级机关老年原发性高血压合并糖代谢异常患者血压变异性（blood pressure variability, BPV），并探讨其对靶器官的影响。方法入选人群为160例老年原发性高血压病人，其中单纯高血压组(A组)55例、高血压合并糖耐量异常组(B组)50例，高血压合并糖尿病(C组)55例，共三组。分别对其进行24小时无创动态血压监测及彩色多普勒超声检查，并计算左心室质量指数（LVMI），分析比较24小时、日间、夜间的血压及其变异性，了解糖代谢异常对高血压患者BPV及左心室产生的影响。结果①高血压合并糖耐量异常组及高血压合并糖尿病组24小时、日间、夜间的血压变异性均显著高于单纯高血压组(P<0.01)；②三组患者LVMI与24小时、日间、夜间的血压及其变异性未见明确正相关(P>0.05)。结论糖代谢异常可以引起高血压患者血压变异性增大，但增大的血压变异性及糖代谢异常并未导致左心室质量指数（LVMI）的显著变化，提示高血压患者靶器官损害受多种因素影响。
목적：응용24h동태혈압감측（24hABPM）분석강소성성급궤관노년원발성고혈압합병당대사이상환자혈압변이성（blood pressure variability, BPV），병탐토기대파기관적영향。방법입선인군위160례노년원발성고혈압병인，기중단순고혈압조(A조)55례、고혈압합병당내량이상조(B조)50례，고혈압합병당뇨병(C조)55례，공삼조。분별대기진행24소시무창동태혈압감측급채색다보륵초성검사，병계산좌심실질량지수（LVMI），분석비교24소시、일간、야간적혈압급기변이성，료해당대사이상대고혈압환자BPV급좌심실산생적영향。결과①고혈압합병당내량이상조급고혈압합병당뇨병조24소시、일간、야간적혈압변이성균현저고우단순고혈압조(P<0.01)；②삼조환자LVMI여24소시、일간、야간적혈압급기변이성미견명학정상관(P>0.05)。결론당대사이상가이인기고혈압환자혈압변이성증대，단증대적혈압변이성급당대사이상병미도치좌심실질량지수（LVMI）적현저변화，제시고혈압환자파기관손해수다충인소영향。
Objective:To investigate the effects of dysglycaemia on patients’ blood pressure variability and target organ damage. Methods 160 hypertension patients are selected and divided into three groups. The experimental groups include:essential hypertension patients (group A, 55 people), and hypertension patients with glucose tolerance abnormal (group B, 50 people),and hypertension patients with diabetes(group B, 55 people). All subjects are tested respectively on 24h blood pressure, color Doppler and left ventricular mass index . The data of BPV and left ventricular mass index are collected and analyzed . Results ①Compared with the group of essential hypertension patients, BPV in the group of hypertension patients with dysglycaemia has increased (P<0.01); ② There are no signiifcant change of left ventricular mass index in three groups. Conclusion Compared with the group of essential hypertension patients, the hypertension patients with dysglycaemia has an obvious increase in BPV, but no obvious difference in left ventricular mass index.