CAJ | 학술논문

目的：探讨NB-UVB对白癜风患者外周血IL-17表达的影响及其可能的免疫学机制。方法38例白癜风患者作为实验组，采用NB-UVB进行治疗，20例健康体检者作为对照组，采用酶联免疫吸附法测定NB-UVB治疗前后白癜风患者及健康体检者外周血IL-17的表达水平。结果白癜风患者外周血IL-17表达水平明显高于对照组，差异有统计学意义(P<0.05)；NB-UVB治疗后白癜风患者外周血IL-17表达水平较治疗前降低，差异有统计学意义(P<0.05)；NB-UVB治疗后白癜风患者外周血IL-17表达水平稍高于对照组，但差异无统计学意义(P>0.05)。结论 NB-UVB可能通过影响白癜风患者外周血中IL-17的表达来发挥治疗作用。
목적：탐토NB-UVB대백전풍환자외주혈IL-17표체적영향급기가능적면역학궤제。방법38례백전풍환자작위실험조，채용NB-UVB진행치료，20례건강체검자작위대조조，채용매련면역흡부법측정NB-UVB치료전후백전풍환자급건강체검자외주혈IL-17적표체수평。결과백전풍환자외주혈IL-17표체수평명현고우대조조，차이유통계학의의(P<0.05)；NB-UVB치료후백전풍환자외주혈IL-17표체수평교치료전강저，차이유통계학의의(P<0.05)；NB-UVB치료후백전풍환자외주혈IL-17표체수평초고우대조조，단차이무통계학의의(P>0.05)。결론 NB-UVB가능통과영향백전풍환자외주혈중IL-17적표체래발휘치료작용。
Objective To study the level of IL-17 in peripheral blood of patients with vitiligo, and to observe the possible mechanism of NB-UVB therapy. Methods The level cytokine in peripheral blood of patients with vitiligo, and to explore the possible immune mechanism of NB-UVB therapy of IL-17 in peripheral blood from 38 vitiligo patients and 20 normal control groups were measured by enzyme linked immunosorbent assay. Results The level of IL-17 in vitiligo patients was higher than the control group (P<0.05);The level of IL-17 in vitiligo patients after NB-UVB therapy was lower, and the difference were signiifcant before treatment (P<0.05);The level of IL-17 in vitiligo patients after NB-UVB therapy was higher than the control group (P>0.05), but the differences were not signiifcant. Conclusion NB-UVB may inlfuence the level of IL-17 cytokine in peripheral blood of patients with vitiligo to plays a therapeutic role.