CAJ | 학술논문

目的：探讨E-cadherin、Ki-67在乳腺髓样癌中表达及临床病理意义。方法采用免疫组织化学方法检测42例乳腺髓样癌中E-cadherin、Ki-67的表达。结果 E-cadherin和Ki-67蛋白表达阳性率在乳腺髓样癌中表达分别为81%（34/42）和76.2%（32/42）。E-cadherin表达阳性率与淋巴结转移呈显著相关（P＜0.05），而与患者年龄、肿瘤大小及是否远处转移无关（P＞0.05）；Ki-67表达及阳性程度随着病理组织学分级、淋巴结转移而增加。结论 E-cadherin和Ki-67蛋白的表达差异是影响乳腺髓样癌预后的重要原因。
목적：탐토E-cadherin、Ki-67재유선수양암중표체급림상병리의의。방법채용면역조직화학방법검측42례유선수양암중E-cadherin、Ki-67적표체。결과 E-cadherin화Ki-67단백표체양성솔재유선수양암중표체분별위81%（34/42）화76.2%（32/42）。E-cadherin표체양성솔여림파결전이정현저상관（P＜0.05），이여환자년령、종류대소급시부원처전이무관（P＞0.05）；Ki-67표체급양성정도수착병리조직학분급、림파결전이이증가。결론 E-cadherin화Ki-67단백적표체차이시영향유선수양암예후적중요원인。
Objective To explore expression of E-cadherin and Ki-67 protein and clinical Pathological significance in the Medullary Carcinoma of Breast. Methods Using immunohistochemical method to detect the expression of E-cadherin and Ki-67in 42 cases of mammary medullary carcinoma. Results E-cadherin and Ki-67 protein expression positive rate in the medullary carcinoma of breast was 81%(34/42) and 76.2%(32/42).E-cadherin expression positive rate was significantly correlated with lymph node metastases(P < 0.05), and regardless of with age of the patient, tumor size, distant metastasis(P > 0.05).Ki-67 expression rate and positive degree increased with pathology histology classification,lymph node metastasis. Conclusion E-adherin and Ki-67 protein expression difference is the important reasons influence breast medullary carcinoma prognosis.