CAJ | 학술논문

目的：观察大剂量吸入普米克令舒雾化溶液与静脉滴注甲基强的松龙注射液辅助治疗AECOPD的临床疗效。方法选取我院2011年10月～2013年4月收治的慢性阻塞性肺疾病急性加重期的患者共计64例。随机分成治疗组和对照组各32例，治疗组在常规抗炎、吸氧等治疗的基础上，给予普米克令舒大剂量雾化吸入联合静脉滴注甲基强的松龙注射液治疗3d后给予大剂量普米克令舒雾化吸入维持，对照组在常规抗炎、吸氧等治疗的基础上，给予普通剂量普米克令舒雾化吸入，两组患者观察周期均定为10d，观察两组患者肺功能、血气分析及临床表现的变化情况。结果两组患者治疗后，治疗组肺功能和血气分析及临床表现方面改善明显高于对照组（P＜0.05），且治疗组患者病情缓解迅速，住院时间明显缩短。结论对于慢性阻塞性肺疾病急性加重期早期应用大剂量吸入普米克令舒雾化溶液与静脉滴注甲基强的松龙注射液辅助治疗，可以明显缩短患者住院时间，迅速缓解症状，且副作用轻微，值得临床借鉴使用。
목적：관찰대제량흡입보미극령서무화용액여정맥적주갑기강적송룡주사액보조치료AECOPD적림상료효。방법선취아원2011년10월～2013년4월수치적만성조새성폐질병급성가중기적환자공계64례。수궤분성치료조화대조조각32례，치료조재상규항염、흡양등치료적기출상，급여보미극령서대제량무화흡입연합정맥적주갑기강적송룡주사액치료3d후급여대제량보미극령서무화흡입유지，대조조재상규항염、흡양등치료적기출상，급여보통제량보미극령서무화흡입，량조환자관찰주기균정위10d，관찰량조환자폐공능、혈기분석급림상표현적변화정황。결과량조환자치료후，치료조폐공능화혈기분석급림상표현방면개선명현고우대조조（P＜0.05），차치료조환자병정완해신속，주원시간명현축단。결론대우만성조새성폐질병급성가중기조기응용대제량흡입보미극령서무화용액여정맥적주갑기강적송룡주사액보조치료，가이명현축단환자주원시간，신속완해증상，차부작용경미，치득림상차감사용。
Objective To observe the clinical curative effect of large doses suction Rupumike respules nebulizer solution and intravenous methylprednisolone injection in the adjunctive therapy of AECOPD. Methods 64 cases of patients with acute exacerbation of chronic obstructive pulmonary disease In our hospital from October 2011 to April 2013 were randomly divided into treatment group and control group,each group was 32 cases. Patients in treatment group were given large doses of Pulmicort inhalation combined with intravenous infusion of methylprednisolone injection based on conventional anti-inflammatory therapy and oxygen uptake,and given large doses of Pulmicort inhalation maintain after 3 days. The control group patients were given large doses of Pulmicort inhalation based on conventional anti-inflammatory therapy and oxygen uptake. The observation periods of two groups were 10 days. The changes of pulmonary function, blood gas analysis and clinical manifestations of two groups were observed. Results The changes of pulmonary function, blood gas analysis and clinical manifestations after treatment in treatment group were higher than the control group(P<0.05). The treatment group patients in remission rapidly, hospitalization time were shortened obviously. Conclusion The application of large doses suction Rupumike respules nebulizer solution and intravenous methylprednisolone injection in the early stage of acute exacerbation of chronic obstructive pulmonary disease can significantly shorten the duration of hospitalization, quickly alleviate the symptoms, and side effects are slight.It is worthy of clinical use.