CAJ | 학술논문

目的：检测乙酰肝素酶（HPA）、蛋白激酶CK2β（CK2β）、缺氧诱导因子-1α（HIF-1α）在NPC组织中的表达的相关性，分析它们的相互关系。方法采用免疫组织化学染色技术Super-Vision法检测49例鼻咽癌（NPC）组织标本中HPA、CK2β及HIF-1α的表达水平。结果HPA、CK2β与HIF-1α任意两者间在NPC组织中的表达均呈正相关关系（P＜0.05）。结论在NPC的发生发展过程中，HPA、CK2β和HIF-1α之间存在协同作用，三者之间可能产生一种“连锁效应”促进了NPC的发生发展。
목적：검측을선간소매（HPA）、단백격매CK2β（CK2β）、결양유도인자-1α（HIF-1α）재NPC조직중적표체적상관성，분석타문적상호관계。방법채용면역조직화학염색기술Super-Vision법검측49례비인암（NPC）조직표본중HPA、CK2β급HIF-1α적표체수평。결과HPA、CK2β여HIF-1α임의량자간재NPC조직중적표체균정정상관관계（P＜0.05）。결론재NPC적발생발전과정중，HPA、CK2β화HIF-1α지간존재협동작용，삼자지간가능산생일충“련쇄효응”촉진료NPC적발생발전。
Objective To investigate the expression of HPA, CK2βand HIF-1αgene in nasopharyngeal carcinoma (NPC) tissues, the relativity of HPA,CK2βand HIF-1αgene in NPC tissues, and analyze the relation between them. Methods HPA, CK2βand HIF-1αwere detected with Super-Vision immunohistochemical method using antibody in 49 NPC specimens. Results The expression of HPA , CK2β and HIF-1α in NPC tissue was positively correlated with each other (P<0.05, separately). Conclusion There could be a positive cooperation among HPA, CK2β and HIF-1αin the carcinogenesis and development of NPC, they may produce a"chain effect"to promote the occurrence and development of NPC.