山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2014年
13期
16-18
,共3页
杨尚瑜%杨梅%王开正%万沁
楊尚瑜%楊梅%王開正%萬沁
양상유%양매%왕개정%만심
糖尿病%诊断价值%血糖
糖尿病%診斷價值%血糖
당뇨병%진단개치%혈당
diabetes mellitus%diagnostic value%blood glucose
目的：对糖尿病（DM）患者血糖三项[餐前血糖、餐后2 h血糖、糖化血红蛋白（HbA1c）]和临床信息进行数据挖掘，评估血糖三项诊断DM的价值。方法回顾性分析泸州地区7614例中老年人血糖三项检测结果及诊断信息，参考美国临床实验室标准化委员会C28-A2文件推荐方法估计55～62岁人群中血糖三项的参考区间，构建诊断和筛查DM的受试者工作曲线（ ROC）数据集，用验后概率来扩展Roc数据集。结果55～62岁人群血糖三项的参考区间分别为：餐前血糖3．89～6．64 mmol/L，餐后2 h血糖4．11～7．73 mmol/L，HbA1c ＜6．2％；血糖三项对DM的诊断价值为餐后2 h血糖＞餐前血糖＞HbA1c ，其ROC下面积分别为0．975、0．887、0．849。诊断DM的切点：餐前血糖6．8 mmol/L；餐后2 h血糖11．0 mmol/L，HbA1c ＜6．2％。经临床实践验证，餐前血糖诊断DM符合率为83．02％，餐后2 h血糖为95．57％。结论血糖三项检验数据挖掘明显提高了DM的诊断价值。
目的：對糖尿病（DM）患者血糖三項[餐前血糖、餐後2 h血糖、糖化血紅蛋白（HbA1c）]和臨床信息進行數據挖掘，評估血糖三項診斷DM的價值。方法迴顧性分析瀘州地區7614例中老年人血糖三項檢測結果及診斷信息，參攷美國臨床實驗室標準化委員會C28-A2文件推薦方法估計55～62歲人群中血糖三項的參攷區間，構建診斷和篩查DM的受試者工作麯線（ ROC）數據集，用驗後概率來擴展Roc數據集。結果55～62歲人群血糖三項的參攷區間分彆為：餐前血糖3．89～6．64 mmol/L，餐後2 h血糖4．11～7．73 mmol/L，HbA1c ＜6．2％；血糖三項對DM的診斷價值為餐後2 h血糖＞餐前血糖＞HbA1c ，其ROC下麵積分彆為0．975、0．887、0．849。診斷DM的切點：餐前血糖6．8 mmol/L；餐後2 h血糖11．0 mmol/L，HbA1c ＜6．2％。經臨床實踐驗證，餐前血糖診斷DM符閤率為83．02％，餐後2 h血糖為95．57％。結論血糖三項檢驗數據挖掘明顯提高瞭DM的診斷價值。
목적：대당뇨병（DM）환자혈당삼항[찬전혈당、찬후2 h혈당、당화혈홍단백（HbA1c）]화림상신식진행수거알굴，평고혈당삼항진단DM적개치。방법회고성분석로주지구7614례중노년인혈당삼항검측결과급진단신식，삼고미국림상실험실표준화위원회C28-A2문건추천방법고계55～62세인군중혈당삼항적삼고구간，구건진단화사사DM적수시자공작곡선（ ROC）수거집，용험후개솔래확전Roc수거집。결과55～62세인군혈당삼항적삼고구간분별위：찬전혈당3．89～6．64 mmol/L，찬후2 h혈당4．11～7．73 mmol/L，HbA1c ＜6．2％；혈당삼항대DM적진단개치위찬후2 h혈당＞찬전혈당＞HbA1c ，기ROC하면적분별위0．975、0．887、0．849。진단DM적절점：찬전혈당6．8 mmol/L；찬후2 h혈당11．0 mmol/L，HbA1c ＜6．2％。경림상실천험증，찬전혈당진단DM부합솔위83．02％，찬후2 h혈당위95．57％。결론혈당삼항검험수거알굴명현제고료DM적진단개치。
Objective To analyze the three items of blood glucose [ fasting plasma glucose ( FPG) , 2 h postprandial glucose (2 h PG) and hemoglobinA1c (HbA1c)] and clinical information deeply, to evaluate their reference ranges and thus to provide the valuable diagnostic information for patients with diabetes mellitus ( DM) .Methods According to the file of C28-A2 at clinical laboratory standardization committee , we retrospectively analyzed three items and diagnostic infor-mation of 7 614 elders in Luzhou , and established the reference ranges of three terms and built the receiver operating char-acteristic curve ( ROC) to diagnose DM and assess diagnosis values .Results The reference ranges of FPG , 2 h PG and HbA1c were 3.89-6.64 mmol/L, 4.11-7.73 mmol/L and HbA1c <6.2%, respectively.The ranks of diagnosis value for DM by FPG, 2 h PG and HbA1c were 2 h PG>FPG>HbA1c, and the area under ROC (AUC) were 0.975, 0.887 and 0.849, respectively.The point of tangency in diagnosis of DM was FPG , 6.8 mmol/L;2 h PG, 11.0mmol/L and HbA1c<6.2%.The diagnostic coincidence rate of FBPG was 83.02%, and 2 h PG was 95.57%.Conclusion The data min-ing of three items of blood glucose significantly improves the DM diagnostic value .
