医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2013年
20期
2665-2666,2669
,共3页
玉屏风颗粒%变应性鼻炎%IL-4%IFN-γ
玉屏風顆粒%變應性鼻炎%IL-4%IFN-γ
옥병풍과립%변응성비염%IL-4%IFN-γ
Yupingfeng particle%AR%IL-4%IFN-γ
目的：研究联合玉屏风颗粒治疗变应性鼻炎（Allergic rhinitis ，AR）的疗效及对AR患者外周血白介素-4（Inter-leukin ，IL-4）和γ-干扰素（Interferon ，IFN-γ）的影响。方法：选择我院耳鼻喉科门诊2010年4月-2013年4月AR患者58例，随机分为治疗组与研究组，研究组在治疗组常规使用抗组胺药、抗白三烯药、鼻用或口服糖皮质激素治疗基础上加用玉屏风颗粒。同时选择健康体检者29例为对照组进行对照研究。治疗前及治疗后1个月、3个月、6个月测定外周血IL-4和IFN-γ的浓度，并观察临床症状及体征。结果：治疗组与研究组在治疗前及治疗期间体征评分比较无明显差异（P＞0．05），IL-4和IFN-γ水平比较无明显差异（P＞0．05）、治疗期间症状评分及疗效两组比较有差异（P＜0．05）。停药后3个月两组在症状及体征评分、疗效、IL-4和IFN-γ的水平均有差异（P＜0．05）。结论：联合玉屏风颗粒治疗AR可提高疗效，对AR患者的免疫状态有恢复作用且作用长久。
目的：研究聯閤玉屏風顆粒治療變應性鼻炎（Allergic rhinitis ，AR）的療效及對AR患者外週血白介素-4（Inter-leukin ，IL-4）和γ-榦擾素（Interferon ，IFN-γ）的影響。方法：選擇我院耳鼻喉科門診2010年4月-2013年4月AR患者58例，隨機分為治療組與研究組，研究組在治療組常規使用抗組胺藥、抗白三烯藥、鼻用或口服糖皮質激素治療基礎上加用玉屏風顆粒。同時選擇健康體檢者29例為對照組進行對照研究。治療前及治療後1箇月、3箇月、6箇月測定外週血IL-4和IFN-γ的濃度，併觀察臨床癥狀及體徵。結果：治療組與研究組在治療前及治療期間體徵評分比較無明顯差異（P＞0．05），IL-4和IFN-γ水平比較無明顯差異（P＞0．05）、治療期間癥狀評分及療效兩組比較有差異（P＜0．05）。停藥後3箇月兩組在癥狀及體徵評分、療效、IL-4和IFN-γ的水平均有差異（P＜0．05）。結論：聯閤玉屏風顆粒治療AR可提高療效，對AR患者的免疫狀態有恢複作用且作用長久。
목적：연구연합옥병풍과립치료변응성비염（Allergic rhinitis ，AR）적료효급대AR환자외주혈백개소-4（Inter-leukin ，IL-4）화γ-간우소（Interferon ，IFN-γ）적영향。방법：선택아원이비후과문진2010년4월-2013년4월AR환자58례，수궤분위치료조여연구조，연구조재치료조상규사용항조알약、항백삼희약、비용혹구복당피질격소치료기출상가용옥병풍과립。동시선택건강체검자29례위대조조진행대조연구。치료전급치료후1개월、3개월、6개월측정외주혈IL-4화IFN-γ적농도，병관찰림상증상급체정。결과：치료조여연구조재치료전급치료기간체정평분비교무명현차이（P＞0．05），IL-4화IFN-γ수평비교무명현차이（P＞0．05）、치료기간증상평분급료효량조비교유차이（P＜0．05）。정약후3개월량조재증상급체정평분、료효、IL-4화IFN-γ적수평균유차이（P＜0．05）。결론：연합옥병풍과립치료AR가제고료효，대AR환자적면역상태유회복작용차작용장구。
Objective :To investigate the curative effect of unite Yupingfeng in AR patients and effect on peripheral blood IL-4 and IFN-γin AR patients .Methods :58 AR patients were chosen in outpatients service of Otorhinolaryngolo-gy from April 2010 to April 2013 .58 AR patients were divided into treatment group and research group in random . Treatment group were treated with drug of antihistamine ,antileukotriene ,intranasal or oral corticosteroids ,Research group were treated with Yupingfeng particle in addition .29 Healthy controls were chosen .Peripheral blood concentra-tion of IL-4 and IFN-γwere measured before treatment and one month ,three months ,six months after treatment .Clini-cal symptoms and physical signs were observed .Results:Grade of physical signs weren’t different before treatment pe-riod and in treatment period between treatment group and research group (P>0 .05) .Peripheral blood serum concen-tration of IL-4 ,IFN-γ were so .Grade of clinical symptoms and curative effect were different in treatment period be-tween treatment group and research group (P<0 .05) .Grade of clinical symptoms and grate of physical signs and ser-um concentration of IL-4 ,IFN-γ were different three month after dug withdrawal .Conclusion:Treatment of unite Yu ping feng can improve efficacy in AR patients .It can improve immune state for long time in AR patients .
