CAJ | 학술논문

目的：评价经皮微波热凝固（percutaneous microwave coagulation therapy，PMCT）治疗周围型非小细胞肺癌的临床价值。方法：总结了2004年3月至2006年9月期间接受经皮微波热凝固疗法的35例非小细胞肺癌患者，并选择同期性别相同、年龄相近、病理类型相同、临床分期相同的放疗患者35例作为对照，观察其疗效进行临床疗效评估，采用Kaplan-Meier法计算生存率， Log-rank检验比较两种方式的生存差异。结果：接受微波热凝固治疗患者的1、3、5年生存率分别为71.4%（25/35）、40.0%（14/35）、20.0%（7/35），接受放射治疗的1、3、5年生存率分别为51.4%（18/35）、22.9%（8/35）、11.4%（4/35），差异有统计学意义（P<0.05）。结论：经皮微波热凝固疗法对因心肺功能差而不能常规手术或恐惧手术创伤的周围型非小细胞肺癌患者是一种微创、安全、有效的好方法。
목적：평개경피미파열응고（percutaneous microwave coagulation therapy，PMCT）치료주위형비소세포폐암적림상개치。방법：총결료2004년3월지2006년9월기간접수경피미파열응고요법적35례비소세포폐암환자，병선택동기성별상동、년령상근、병리류형상동、림상분기상동적방료환자35례작위대조，관찰기료효진행림상료효평고，채용Kaplan-Meier법계산생존솔， Log-rank검험비교량충방식적생존차이。결과：접수미파열응고치료환자적1、3、5년생존솔분별위71.4%（25/35）、40.0%（14/35）、20.0%（7/35），접수방사치료적1、3、5년생존솔분별위51.4%（18/35）、22.9%（8/35）、11.4%（4/35），차이유통계학의의（P<0.05）。결론：경피미파열응고요법대인심폐공능차이불능상규수술혹공구수술창상적주위형비소세포폐암환자시일충미창、안전、유효적호방법。
Objective:To evaluate the clinical value of percutaneous microwave coagulation therapy for peripheral non-small-cell lung cancer. Methods:We evaluated 35 patients with non-small-cell lung cancer who received percutaneous microwave coagulation therapy and 35 patients who received radiotherapy from March 2004 to September 2006;the patients were sex-matched, age-matched, and had the same pathology and clinical staging. Clinical effects were observed and assessed. Survival rate were calculated using the Kaplan-Meier method. The difference in survival rate between the two treatment methods was analyzed using a log-rank test. Results:The 1-year, 3-year, and 5-year survival rates for the microwave coagulation therapy group (71.4%, 40.0%, and 20.0%, respectively) were significantly higher than those for the radiation therapy (51.4%, 22.9%, and 11.4%, respectively) (P<0.05). Conclusion:Percutaneous microwave coagulation therapy is a minimally invasive, safe, and effective alternative for patients with peripheral non-small-cell lung cancer who cannot undergo routine surgery because of poor heart and lung function or fear of surgical trauma.