中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2013年
21期
1309-1313
,共5页
鼻咽癌%中性粒细胞%白蛋白%预后
鼻嚥癌%中性粒細胞%白蛋白%預後
비인암%중성립세포%백단백%예후
nasopharyngeal carcinoma%neutrophil%albumin%prognosis
目的：研究治疗前中性粒细胞、淋巴细胞、单核细胞及白蛋白水平与鼻咽癌患者预后的相关性。方法：选取401例在中山大学肿瘤医院进行初次诊断的鼻咽癌患者。记录患者免疫相关参数值及白蛋白水平。Kaplan-Meier和Log-rank分析比较总生存期和无进展生存期。采用Cox回归风险模型来确定预后因素。结果：治疗前高中性粒细胞>5.20×109/L（n=172）患者在总生存期和无进展生存期上均小于治疗前低中性粒细胞≤5.20×109/L（n=229）患者（P=0.014，P=0.009）。治疗前高白蛋白水平组>43.00 g/L（n=253）在总生存期和无进展生存期均高于治疗前低白蛋白组≤43.00 g/L（n=148）（P<0.001，P=0.006）。多因素分析发现治疗前中性粒细胞数目是鼻咽癌患者无进展生存期的独立预后因素，治疗前白蛋白水平是鼻咽癌患者总生存期的独立预后因素。结论：治疗前外周血中性粒细胞数目与白蛋白水平可作为鼻咽癌患者生存的独立预后因素。
目的：研究治療前中性粒細胞、淋巴細胞、單覈細胞及白蛋白水平與鼻嚥癌患者預後的相關性。方法：選取401例在中山大學腫瘤醫院進行初次診斷的鼻嚥癌患者。記錄患者免疫相關參數值及白蛋白水平。Kaplan-Meier和Log-rank分析比較總生存期和無進展生存期。採用Cox迴歸風險模型來確定預後因素。結果：治療前高中性粒細胞>5.20×109/L（n=172）患者在總生存期和無進展生存期上均小于治療前低中性粒細胞≤5.20×109/L（n=229）患者（P=0.014，P=0.009）。治療前高白蛋白水平組>43.00 g/L（n=253）在總生存期和無進展生存期均高于治療前低白蛋白組≤43.00 g/L（n=148）（P<0.001，P=0.006）。多因素分析髮現治療前中性粒細胞數目是鼻嚥癌患者無進展生存期的獨立預後因素，治療前白蛋白水平是鼻嚥癌患者總生存期的獨立預後因素。結論：治療前外週血中性粒細胞數目與白蛋白水平可作為鼻嚥癌患者生存的獨立預後因素。
목적：연구치료전중성립세포、림파세포、단핵세포급백단백수평여비인암환자예후적상관성。방법：선취401례재중산대학종류의원진행초차진단적비인암환자。기록환자면역상관삼수치급백단백수평。Kaplan-Meier화Log-rank분석비교총생존기화무진전생존기。채용Cox회귀풍험모형래학정예후인소。결과：치료전고중성립세포>5.20×109/L（n=172）환자재총생존기화무진전생존기상균소우치료전저중성립세포≤5.20×109/L（n=229）환자（P=0.014，P=0.009）。치료전고백단백수평조>43.00 g/L（n=253）재총생존기화무진전생존기균고우치료전저백단백조≤43.00 g/L（n=148）（P<0.001，P=0.006）。다인소분석발현치료전중성립세포수목시비인암환자무진전생존기적독립예후인소，치료전백단백수평시비인암환자총생존기적독립예후인소。결론：치료전외주혈중성립세포수목여백단백수평가작위비인암환자생존적독립예후인소。
Objective:To investigate the association of pretherapeutic neutrophil, lymphocyte, monocyte, and serum albumin levels with nasopharyngeal carcinoma (NPC) prognosis in 401 patients. Methods:This study involved 401 NPC patients recently diagnosed and admitted in Sun Yat-sen University Cancer Center, China. Laboratory variables, such as immunology-related parameters and albumin level prior to treatment, were analyzed. The overall survival and disease-free survival rates were determined using the Kaplan-Meier method and were then compared using the log-rank test. Univariate and multivariate analyses were performed using the Cox proportional hazards model to identify prognostic factors. Results:Patients with neutrophil counts>5.20×109/L (n=172) had significantly lower overall survival and disease-free survival rates compared with those with neutrophil counts≤5.20×109/L (n=229) (P=0.014, P=0.009). In the 401 NPC cases, patients with high albumin levels (>43.00 g/L;n=253) had significantly higher overall survival (P=0.000) and disease-free survival (P=0.006) rates compared with those with low albumin levels (≤43.00 g/L;n=148). Multivariate analysis showed that the neutrophil level is an in-dependent risk factor for disease-free survival, whereas the albumin level is a strong independent prognostic factor for overall survival. Conclusion:The pretherapeutic neutrophil and albumin levels are independent prognostic factors for survival in NPC patients.
