检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2013年
21期
2829-2830
,共2页
肺疾病%干扰素-γ%肿瘤坏死因子-α%内皮素-1
肺疾病%榦擾素-γ%腫瘤壞死因子-α%內皮素-1
폐질병%간우소-γ%종류배사인자-α%내피소-1
pulmonary disease%IFN-γ%TNF-α%ET-1
目的：分析探讨慢性阻塞性肺疾病（COPD）患者血清干扰素-γ（IFN-γ）、肿瘤坏死因子-α（TNF-α）和内皮素-1（ET-1）与肺功能关系的临床意义。方法采集COPD急性加重期、缓解期患者外周血，另外选择健康者作为健康对照组，采用酶联免疫法分别检测血清中IFN-γ、TNF-α和ET-1的水平。结果 COPD急性加重期和缓解期患者血清IFN-γ、TNF-α和 ET-1的水平明显高于健康对照组，组间比较差异有统计学意义（P＜0．05），与COPD缓解期患者IFN-γ、TNF-α和ET-1的水平比较，急性加重期患者IFN-γ、TNF-α和ET-1的水平明显增高，两组比较差异有统计学意义（P＜0．05）。结论 COPD 患者血清IFN-γTNF-α和ET-1的水平与肺功能及病情变化密切相关，血清IFN-γ、TNF-α和ET-1水平的变化可衡量 COPD 病情严重程度和判断患者的疗效及预后。
目的：分析探討慢性阻塞性肺疾病（COPD）患者血清榦擾素-γ（IFN-γ）、腫瘤壞死因子-α（TNF-α）和內皮素-1（ET-1）與肺功能關繫的臨床意義。方法採集COPD急性加重期、緩解期患者外週血，另外選擇健康者作為健康對照組，採用酶聯免疫法分彆檢測血清中IFN-γ、TNF-α和ET-1的水平。結果 COPD急性加重期和緩解期患者血清IFN-γ、TNF-α和 ET-1的水平明顯高于健康對照組，組間比較差異有統計學意義（P＜0．05），與COPD緩解期患者IFN-γ、TNF-α和ET-1的水平比較，急性加重期患者IFN-γ、TNF-α和ET-1的水平明顯增高，兩組比較差異有統計學意義（P＜0．05）。結論 COPD 患者血清IFN-γTNF-α和ET-1的水平與肺功能及病情變化密切相關，血清IFN-γ、TNF-α和ET-1水平的變化可衡量 COPD 病情嚴重程度和判斷患者的療效及預後。
목적：분석탐토만성조새성폐질병（COPD）환자혈청간우소-γ（IFN-γ）、종류배사인자-α（TNF-α）화내피소-1（ET-1）여폐공능관계적림상의의。방법채집COPD급성가중기、완해기환자외주혈，령외선택건강자작위건강대조조，채용매련면역법분별검측혈청중IFN-γ、TNF-α화ET-1적수평。결과 COPD급성가중기화완해기환자혈청IFN-γ、TNF-α화 ET-1적수평명현고우건강대조조，조간비교차이유통계학의의（P＜0．05），여COPD완해기환자IFN-γ、TNF-α화ET-1적수평비교，급성가중기환자IFN-γ、TNF-α화ET-1적수평명현증고，량조비교차이유통계학의의（P＜0．05）。결론 COPD 환자혈청IFN-γTNF-α화ET-1적수평여폐공능급병정변화밀절상관，혈청IFN-γ、TNF-α화ET-1수평적변화가형량 COPD 병정엄중정도화판단환자적료효급예후。
Objective To explore the clinic significance of IFN-γ,TNF-α and ET-1 in patients with COPD . Methods The peripheral blood of patients with COPD in acute exacerbation ,in catabasis and healthy person was col-lected .Serum level of IFN-γ,TNF-αand ET-1 were detected by ELISA .Results Levels of IFN-γ,TNF-αand ET-1 in the cases of COPD in acute exacerbation and catabasis were higher than those of the healthy person (P<0 .05) . Levels of IFN-γ,TNF-αand ET-1 in the period of acute exacerbation were significantly higher than those in the cata-basis(P<0 .05) .Conclusion The level of the serum IFN-γ,TNF-αand ET-1 and lung function are closely related to the changing of the patient′s conditions .Serum IFN-γ,TNF-αand ET-1 can be used to judge the severity of the ill-ness and also be used to estimate the curative effect and prognosis .
