CAJ | 학술논문

目的：探讨创伤脓毒症患者外周血T h17/T reg水平变化和临床意义。方法选取该院2010年1月至2011年12月收治的40例创伤脓毒症患者作为研究组，并选取同期未发生脓毒症的40例创伤患者为对照1组和40例健康者为对照2组，并采取流式细胞术检测三组外周血T h17和T reg水平变化情况。结果通过三组的检测结果比较，研究组外周血T h17/T reg明显的高于对照1组和对照2组，组间比较差异有统计学意义（ P＜0．05）；而对照1组外周血T h17/T reg和对照2组比较差异无统计学意义（ P＞0．05）；在研究组中，不同病情程度患者外周血T h17/T reg也不相同，且脓毒症休克患者外周血T h17/T reg大于脓毒症重症患者，后者则大于脓毒症轻度患者，两两数据比较差异有统计学有意义（ P＜0．05）。结论创伤脓毒症患者外周血 T h17/T reg水平异常升高，并且随着患者病情程度的加重，其T h17/T reg水平也明显的升高。可以通过检测外周血T h17/T reg水平判断创伤脓毒症患者的病情状况，在临床中具有重要的实际意义。
목적：탐토창상농독증환자외주혈T h17/T reg수평변화화림상의의。방법선취해원2010년1월지2011년12월수치적40례창상농독증환자작위연구조，병선취동기미발생농독증적40례창상환자위대조1조화40례건강자위대조2조，병채취류식세포술검측삼조외주혈T h17화T reg수평변화정황。결과통과삼조적검측결과비교，연구조외주혈T h17/T reg명현적고우대조1조화대조2조，조간비교차이유통계학의의（ P＜0．05）；이대조1조외주혈T h17/T reg화대조2조비교차이무통계학의의（ P＞0．05）；재연구조중，불동병정정도환자외주혈T h17/T reg야불상동，차농독증휴극환자외주혈T h17/T reg대우농독증중증환자，후자칙대우농독증경도환자，량량수거비교차이유통계학유의의（ P＜0．05）。결론창상농독증환자외주혈 T h17/T reg수평이상승고，병차수착환자병정정도적가중，기T h17/T reg수평야명현적승고。가이통과검측외주혈T h17/T reg수평판단창상농독증환자적병정상황，재림상중구유중요적실제의의。
Objective To investigate the changes of Th17/Treg levels of peripheral blood in patients with posttraumatic sepsis and the clinical significance .Methods 40 cases of traumatic sepsis were enrolled as study group from 2010 January to 2011 December in our hospital ,40 cases of trauma without sepsis as control group 1 and 40 healthy subjects as control group 2 .The Th17 and Treg level in blood were detected by flow cytometry in three groups .Results The peripheral blood Th17/Treg value in study group value was higher than that of control group 1 and control group 2 ,and the difference was significant(P<0 .05) .While there was no difference in Th17/Treg 1 val-ue of peripheral blood between the control group 1and control group 2(P> 0 .05) .In the study group ,peripheral blood Th17/Treg value in patients with different severity was not the same ,and peripheral blood Th17/Treg value in septic shock patients was higher than that in patients with severe sepsis patients ,the latter was higher than that in mild sepsis patients ,and the difference was significant(P<0 .05) .Conclusion The level of Th17/Treg of peripheral blood in sepsis patients was abnormally increased ,along with the aggravation of the severity of sepsis .The detection of peripheral blood Th17/Treg level could judge the pathogenetic condition of sepsis ,and it has importantly practical significance in clinical practice .