CAJ | 학술논문

目的：探讨本地区社区皮肤及软组织感染（SSTIs）病原菌分布及其耐药性，为临床合理用药提供科学依据。方法对该院2009年1月至2012年12月符合社区SSTIs诊断标准的患者留取分泌物或脓液等标本进行细菌培养、病原菌鉴定及药物敏感试验，使用WHONET5．5软件进行分析。结果革兰阳性球菌占85．3％，金黄色葡萄球菌占54．6％，耐甲氧西林金黄色葡萄球菌（M RSA ）检出率3．1％。甲氧西林敏感金黄色葡萄球菌（MSSA）、MRSA对青霉素、氨苄青霉素、红霉素耐药率分别高于90％、90％、70％，未检出对万古霉素、替考拉宁、利奈唑胺耐药的葡萄球菌。结论金黄色葡萄球菌是本地区社区SSTIs最常见的病原菌，临床应做到有样必采以确定病原菌，合理使用抗菌药物以减缓耐药菌产生。
목적：탐토본지구사구피부급연조직감염（SSTIs）병원균분포급기내약성，위림상합리용약제공과학의거。방법대해원2009년1월지2012년12월부합사구SSTIs진단표준적환자류취분비물혹농액등표본진행세균배양、병원균감정급약물민감시험，사용WHONET5．5연건진행분석。결과혁란양성구균점85．3％，금황색포도구균점54．6％，내갑양서림금황색포도구균（M RSA ）검출솔3．1％。갑양서림민감금황색포도구균（MSSA）、MRSA대청매소、안변청매소、홍매소내약솔분별고우90％、90％、70％，미검출대만고매소、체고랍저、리내서알내약적포도구균。결론금황색포도구균시본지구사구SSTIs최상견적병원균，림상응주도유양필채이학정병원균，합리사용항균약물이감완내약균산생。
Objective To investigate the distribution of pathogens caused skin and soft-tissue infection and de-termine the major pathogens susceptibility to antimicrobial agents in the community .Methods The pus or wound se-cretion of out-patients with skin and soft tissue infection were collected .Bacterial culture and identification were per-formed .The major pathogens susceptibility to antimicrobial agents was tested .Results Of 348 pathogens ,gram posi-tive coccus accounted for 85 .3% and S .aureus accounted for 54 .6% .The prevalence of MRSA in S .aureus was 3 .1% .The resistance rate of Staphylococcus spp .to penicillin ,ampicillin and erythromycin were more than 90% , 90% ,and 70% ,respectively .No staphylococcus isolates was found resistant to vancomycin ,teicoplanin or linezolid . Conclusion S .aureus was the major pathogenic bacterium for skin and soft tissue infection in the community of Lanzhou .The low prevalence of CR -MRSA was observed .Penicillin ,ampicillin and erythromycin should not be the first choice for practical treating skin and soft -tissue infections .Rational drug use scheme is called in clinical prac-tice to prevent development of high level resistance .