CAJ | 학술논문

目的：探讨CYP2C19基因多态性对质子泵抑制剂联合阿莫西林与克拉霉素三联疗法根除幽门螺杆菌（H p ）的影响。方法选择90例H p阳性的消化性溃疡患者，随机分成观察组与对照组，每组45例，所有患者均于治疗前测定CYP2C19基因型，分为EM、IM及PM型。观察组给予雷贝拉唑＋阿莫西林＋克拉霉素口服，对照组给予奥美拉唑＋阿莫西林＋克拉霉素口服，两组均治疗1周。停药4周后检测 Hp根除情况。结果观察组与对照组Hp根除率分别为85．7％和77．8％，差异无统计学意义（P＞0．05）；观察组EM、IM、PM 型 Hp根除率及各基因分型比较，差异无统计学意义（P＞0．05）；对照组 EM 与 IM、EM 与 PM 之间 Hp根除率差异有统计学意义（P＜0．01），IM与PM 间差异无统计学意义（P＞0．05）。结论 CYP2C19基因多态性对雷贝拉唑联合阿莫西林与克拉霉素三联疗法 Hp根除率无明显影响，对奥美拉唑联合阿莫西林与克拉霉素三联疗法的Hp根除率影响较大。
목적：탐토CYP2C19기인다태성대질자빙억제제연합아막서림여극랍매소삼련요법근제유문라간균（H p ）적영향。방법선택90례H p양성적소화성궤양환자，수궤분성관찰조여대조조，매조45례，소유환자균우치료전측정CYP2C19기인형，분위EM、IM급PM형。관찰조급여뢰패랍서＋아막서림＋극랍매소구복，대조조급여오미랍서＋아막서림＋극랍매소구복，량조균치료1주。정약4주후검측 Hp근제정황。결과관찰조여대조조Hp근제솔분별위85．7％화77．8％，차이무통계학의의（P＞0．05）；관찰조EM、IM、PM 형 Hp근제솔급각기인분형비교，차이무통계학의의（P＞0．05）；대조조 EM 여 IM、EM 여 PM 지간 Hp근제솔차이유통계학의의（P＜0．01），IM여PM 간차이무통계학의의（P＞0．05）。결론 CYP2C19기인다태성대뢰패랍서연합아막서림여극랍매소삼련요법 Hp근제솔무명현영향，대오미랍서연합아막서림여극랍매소삼련요법적Hp근제솔영향교대。
Objective To study the CYP2C19 gene polymorphisms on triple therapy with a proton pump in-hibitor ,amoxicillin and clarithromycin for eradication of helicobacter pylori (Hp) .Methods 90 peptic ulcer patients of Hp positive were randomly divided into observation group and control group ,45 cases in each group .CYP2C19 geno-type in all patients were measured before treatment ,and divided into EM ,IM and PM .The patients in observation group were given rabeprazole ,amoxicillin and clarithromycin orally ,and the patients in control group were given ome-prazole ,amoxicillin and clarithromycin orally .The two groups were treated for 1 week .Hp eradication was detected 4 weeks after drug withdrawal .Results The Hp eradication rate in observation group and control group were 85 .7%and 77 .8% ,respectively .There was no statistical difference(P>0 .05) .The each genotyping of EM ,IM and PM Hp eradication rate in observation group had no statistical difference (P>0 .05) .The difference of Hp eradication rate be-tween EM and IM ,EM and PM in control group were significant (P<0 .01) ,and there was no significant difference between IM and PM (P>0 .05) .Conclusion CYP2C19 gene polymorphisms have no obvious influence on the Hp e-radication rate of triple therapy with rabeprazole ,amoxicillin and clarithromycin ,but greatly affect the Hp eradication rate of the triple therapy with omeprazole ,amoxicillin and clarithromycin .