CAJ | 학술논문

目的：通过茂名地区鼻咽癌高危人群筛查，对其中部分高危人群进行追踪研究，希望达到预防或减少鼻咽癌发生。方法：使用改良 ELISA 法，在2005---2010年间，共筛查有EBVCA/IgA(+)850人（下称筛查组）；随机抽取部分EBVCA/IgA(+)患者360例（下称研究组），采取切断EB病毒感染人群体液传播途径的方法，每半年进行追踪检测一次EBVCA/IgA的S/CO值；随机抽取EBVCA/IgA(-)正常人群300例（下称对照组）进行配对EBVCA/IgA检测。结果：筛查组EBVCA/IgA(+)的S/CO平均值为1.933；研究组第一次EBVCA/IgA的S/CO平均值为1.523；研究组第二次EBVCA/IgA的S/CO平均值为1.505；研究组第三次EBVCA/IgA的S/CO平均值为1.501；研究组第四次EBVCA/IgA的S/CO平均值为1.495；对照组EBVCA/IgA的S/CO平均值为0.712；经统计学分析，筛查组与研究组之间存在统计学差异（p<0.05）。结论：通过鼻咽癌高危人群筛查，对高危人群给予特殊关怀(如通过切断 EB 病毒感染人群体液途径等方法)，有望降低鼻咽癌的发生率。
목적：통과무명지구비인암고위인군사사，대기중부분고위인군진행추종연구，희망체도예방혹감소비인암발생。방법：사용개량 ELISA 법，재2005---2010년간，공사사유EBVCA/IgA(+)850인（하칭사사조）；수궤추취부분EBVCA/IgA(+)환자360례（하칭연구조），채취절단EB병독감염인군체액전파도경적방법，매반년진행추종검측일차EBVCA/IgA적S/CO치；수궤추취EBVCA/IgA(-)정상인군300례（하칭대조조）진행배대EBVCA/IgA검측。결과：사사조EBVCA/IgA(+)적S/CO평균치위1.933；연구조제일차EBVCA/IgA적S/CO평균치위1.523；연구조제이차EBVCA/IgA적S/CO평균치위1.505；연구조제삼차EBVCA/IgA적S/CO평균치위1.501；연구조제사차EBVCA/IgA적S/CO평균치위1.495；대조조EBVCA/IgA적S/CO평균치위0.712；경통계학분석，사사조여연구조지간존재통계학차이（p<0.05）。결론：통과비인암고위인군사사，대고위인군급여특수관부(여통과절단 EB 병독감염인군체액도경등방법)，유망강저비인암적발생솔。
Objective:To reduce the rate of nasopharyngeal carcinoma for high dangerous people. Methods:Modified ELISA was applied to measuring serum EBVCA/IgA in 850 EBVCA/IgA(+)original controls(original control group) and in 300 healthy controls (healthy control group), 360 EBVCA/IgA(+) subjects(study group:the first time 90, the second time 180, the third time 270 , and the forth time 360 ).Results:Modified ELISA results of EBVCA/IgA were 1.933 in serum of original controls, 1.523 in serum of study group in the first time , 1.505 in serum of study group in the second time, 1.501 in serum of study group in the third time, 1.495 in serum of study group in the forth time, and 0.712 in serum of healthy control group .Statistical analysis of modified ELISA EBVCA/IgA results showed there was significant difference between original control group and study group . Conclusion:The means to reduce the rate of nasopharyngeal carcinoma for deference Epstein-Barr virus liquid travel is useful .