CAJ | 학술논문

目的：明确自然流产夫妇中各染色体异常的发生率，并探讨染色体异常与性别、自然流产发生次数、流产发生时间以及既往生育史的关系。方法：对1770对自然流产受检夫妇进行外周血淋巴细胞染色体核型分析。结果：共检出111例（3.14%）异常核型，119例（3.36%）多态核型；受检男性中染色体异常共41例（2.32%），女性中染色体异常共70例（3.95%）；染色体异常的夫妇既往异常生育率为6.36%，既往正常生育率为1.8%。染色体异常夫妇与染色体正常夫妇的早期流产发生率差异无统计学意义（P＞0.05）；染色体易位者多次自然流产发生率（55.1%）较染色体正常者（25.0%）偏高（P＜0.001），而倒位者多次自然流产发生率（30.2%）与染色体正常者差异无统计学意义（P＞0.05）。染色体异染色质及随体多态者多次流产发生率（37.3%）与正常者及易位者差异均有统计学意义（P=0.007及P=0.036）。结论：在自然流产夫妇中女性染色体异常率较男性高；夫妇双方染色体异常与自然流产次数、既往生育史关系密切，是其重要的致病因素。
목적：명학자연유산부부중각염색체이상적발생솔，병탐토염색체이상여성별、자연유산발생차수、유산발생시간이급기왕생육사적관계。방법：대1770대자연유산수검부부진행외주혈림파세포염색체핵형분석。결과：공검출111례（3.14%）이상핵형，119례（3.36%）다태핵형；수검남성중염색체이상공41례（2.32%），녀성중염색체이상공70례（3.95%）；염색체이상적부부기왕이상생육솔위6.36%，기왕정상생육솔위1.8%。염색체이상부부여염색체정상부부적조기유산발생솔차이무통계학의의（P＞0.05）；염색체역위자다차자연유산발생솔（55.1%）교염색체정상자（25.0%）편고（P＜0.001），이도위자다차자연유산발생솔（30.2%）여염색체정상자차이무통계학의의（P＞0.05）。염색체이염색질급수체다태자다차유산발생솔（37.3%）여정상자급역위자차이균유통계학의의（P=0.007급P=0.036）。결론：재자연유산부부중녀성염색체이상솔교남성고；부부쌍방염색체이상여자연유산차수、기왕생육사관계밀절，시기중요적치병인소。
Objective:To estimate the frequency of chromosomal abnormalities, and to explore the relationship between chromosomal abnormalities and sex,abortion times,gestational age and abnormal childbearing history. Methods:The chromosome karyotyping and clinical characteristics were retrospectively analyzed in 1 770 couples with spontaneous abortion. Results:Chromosomal abnormalities and polymorphisms were detected in 111 cases (3.14%) and 119 cases (3.36%), respectively. 41 cases (2.32%) of chromosomal abnormalities were found in male while 70 cases (3.95%) in female. The abnormal childbearing rate in those chromosome-abnormal couples was 6.36%, while the normal childbearing rate in those couples was 1.8%, respectively. There was no significant difference in early miscarriage rates between those abnormality couples and controls (P>0.05). The rate of spontaneous abortion in those couples with chromosomal translocation (55.1%) was higher than that in normal couples (25.0%,P<0.001), while this rate in those couples with chromosomal inversion did not significantly change (P>0.05). There was significant difference in the rate of multiple spontaneous abortion in those heterochromatin/satellite heteromorphism carriers ( 37 . 3%) when compared with normal couples as well as chromosome-translocation couples (P=0.007,P=0.036). Conclusions:In those couples with spontaneous abortion, the rate of chromosomal abnormalities was more frequent in female than that in male. Chromosomal abnormalities were closely related to abortion times, abnormal childbearing history, suggesting that chromosomal abnormalities are risk factors of spontaneous abortion.