CAJ | 학술논문

目的探讨老年高血压患者脉压及脉压指数与肾脏功能变化的关系。方法选取本院2011年2月至2012年10月老年高血压患者147例为观察组，选取本院同期老年健康体检人员135例为对照组，检测血压，根据公式计算脉压和脉压指数，同时检测肾功指标，分析脉压及脉压指数与肾脏功能的相关性。结果观察组舒张压、收缩压、脉压、脉压指数、尿微量白蛋白、血β2微球蛋白、尿素氮、血肌酐均明显高于对照组；观察组肾小球滤过率明显低于对照组，差异均有显著性(P<0.05)。脉压、脉压指数、尿微量白蛋白、血β2微球蛋白、尿素氮、血肌酐各指标间为正相关性，肾小球滤过率与其他指标为负相关性。结论老年高血压患者脉压及脉压指数与肾脏功能相关，脉压越高，脉压指数越大，肾功能指标越差。脉压与脉压指数可作为肾脏功能的有效监测指标。
목적탐토노년고혈압환자맥압급맥압지수여신장공능변화적관계。방법선취본원2011년2월지2012년10월노년고혈압환자147례위관찰조，선취본원동기노년건강체검인원135례위대조조，검측혈압，근거공식계산맥압화맥압지수，동시검측신공지표，분석맥압급맥압지수여신장공능적상관성。결과관찰조서장압、수축압、맥압、맥압지수、뇨미량백단백、혈β2미구단백、뇨소담、혈기항균명현고우대조조；관찰조신소구려과솔명현저우대조조，차이균유현저성(P<0.05)。맥압、맥압지수、뇨미량백단백、혈β2미구단백、뇨소담、혈기항각지표간위정상관성，신소구려과솔여기타지표위부상관성。결론노년고혈압환자맥압급맥압지수여신장공능상관，맥압월고，맥압지수월대，신공능지표월차。맥압여맥압지수가작위신장공능적유효감측지표。
Objective To investigate clinical effect of telmisartan and salvianolate in treatment for elderly secondary chronic kidney disease. Method 78 elder patients with secondary chronic kidney disease were selected in hospital from January 2011 to February 2012,who were randomly divided into two groups. 39 patients oral telmisartan as control group. 39 patients oral telmisartan and injected salvianolate as observation group. Course of treatment was 1 year. Various clinical indications and clinical efficacy were compared between two groups before and after treatment. Result Observation group of diastolic and systolic blood pressure, pulse pressure, pulse pressure index, the urine trace albumin, blood beta 2 microglobulin, urea nitrogen, serum creatinine were significantly higher than control group;Glomerular filtration rate observation group was obviously lower than the control group, the differences were significant (P<0. 05). Pulse pressure, pulse pressure index, the urine trace albumin, blood beta 2 microglobulin, urea nitrogen, serum creatinine is positive correlation among the indexes, glomerular filtration rate and other indica-tors have a negative correlation. Conclusion Telmisartan and salvianolate are effective methods in treatment for eld-erly secondary chronic kidney disease,which can significantly improve clinical symptoms and cure rate. That also has high security and worthy of clinical use.