CAJ | 학술논문

目的：研究 p27、基质金属蛋白酶（MMP）-2、MMP-9在结肠癌中的表达及意义。方法采用免疫组化SP 法检测50例结肠癌组织、癌旁组织和正常切缘组织中的 p27、MMP-2、MMP-9。结果结肠癌组织、肿瘤外围3 cm和正常切缘中，p27、MMP-2和 MMP-9阳性率比较，差异有统计学意义（ P ＜0．05）。癌组织中 p27、MMP-2和 MMP-9表达在肿瘤的不同分化程度、Dukes 分期及有无淋巴结转移间比较，差异有统计学意义（ P ＜0．05）。结论p27的低表达和 MMP-2、MMP-9的过表达在结肠癌的发生发展及其浸润和转移中具有重要作用。
목적：연구 p27、기질금속단백매（MMP）-2、MMP-9재결장암중적표체급의의。방법채용면역조화SP 법검측50례결장암조직、암방조직화정상절연조직중적 p27、MMP-2、MMP-9。결과결장암조직、종류외위3 cm화정상절연중，p27、MMP-2화 MMP-9양성솔비교，차이유통계학의의（ P ＜0．05）。암조직중 p27、MMP-2화 MMP-9표체재종류적불동분화정도、Dukes 분기급유무림파결전이간비교，차이유통계학의의（ P ＜0．05）。결론p27적저표체화 MMP-2、MMP-9적과표체재결장암적발생발전급기침윤화전이중구유중요작용。
Objective To investigate the expressions and clinical significance of p 27,MMP-2,MMP-9 in colon carcinoma.Methods Immunohistochemistry was used to detect the expression of p 27,MMP-2,MMP-9 in 50 specimens of colon carcinoma tissues,the tissues around cancer and normal tissues from resection margin .Results In colon cancer tissues, the tissues 3 cm away from cancer and normal colon tissues ,the positive expression rates of p27 were 54%,90%,100%, MMP-2 were 76%,20%,0 and MMP-9 were 82%,44%,0,respectively.There were significant differences in the positive expression rates of p27,MMP-2 and MMP-9 among the three kinds of tissues ( P <0.05).The expressions of p27,MMP-2 and MMP-9 in cancer tissues were closely correlated to the differentiation degree ,Dukes staging and lymph node metastases (P <0.01).Conclusion The lower-expression of p27 and overexpression of MMP-2 and MMP-9 play an important role in the pathogenesis,development,infiltration and metastasis of colon carcinoma .