遗传
遺傳
유전
HEREDITAS(BEIJING)
2014年
5期
403-410
,共8页
DNA甲基化%去甲基化%表观遗传学%稳态%转化研究
DNA甲基化%去甲基化%錶觀遺傳學%穩態%轉化研究
DNA갑기화%거갑기화%표관유전학%은태%전화연구
DNA methylation%demethylation%epigenetics%homeostasis%translational research
DNA甲基化通过调节基因转录、印记、X染色体灭活和防御外源性遗传物质入侵等，在细胞分化、胚胎发育、环境适应和疾病发生发展上发挥重要作用，是当前表观遗传学研究的热点领域之一。文章介绍了在过去几年中TET介导的DNA羟甲基化及其在早期胚胎发育中的作用， DNA主动去甲基化及其与被动去甲基化的关系， DNA甲基化建立及其与组蛋白修饰、染色质构象、多梳蛋白和非编码RNA结合等关系方面的重要研究进展和存在的问题以及DNA甲基化的转化应用前景。
DNA甲基化通過調節基因轉錄、印記、X染色體滅活和防禦外源性遺傳物質入侵等，在細胞分化、胚胎髮育、環境適應和疾病髮生髮展上髮揮重要作用，是噹前錶觀遺傳學研究的熱點領域之一。文章介紹瞭在過去幾年中TET介導的DNA羥甲基化及其在早期胚胎髮育中的作用， DNA主動去甲基化及其與被動去甲基化的關繫， DNA甲基化建立及其與組蛋白脩飾、染色質構象、多梳蛋白和非編碼RNA結閤等關繫方麵的重要研究進展和存在的問題以及DNA甲基化的轉化應用前景。
DNA갑기화통과조절기인전록、인기、X염색체멸활화방어외원성유전물질입침등，재세포분화、배태발육、배경괄응화질병발생발전상발휘중요작용，시당전표관유전학연구적열점영역지일。문장개소료재과거궤년중TET개도적DNA간갑기화급기재조기배태발육중적작용， DNA주동거갑기화급기여피동거갑기화적관계， DNA갑기화건립급기여조단백수식、염색질구상、다소단백화비편마RNA결합등관계방면적중요연구진전화존재적문제이급DNA갑기화적전화응용전경。
DNA methylation plays important roles in cell differentiation, embryonic development, host adaptations to environmental factors, and pathogenesis through regulation of gene transcription and imprinting, X-inactivation, and de-fense of foreign genetic material invasion, is currently one of the hottest research fields on epigenetics. In the past few years, a number of important findings on DNA methylation have been achieved. These findings include discovery of TETs-catalyzed cytosine hydroxymethylation and its functions in the early embryonic development; the relationship be-tween active and passive DNA demethylation;establishment and maintenance of DNA methylation patterns and their asso-ciations with histone modifications, chromatin configuration, polycomb group proteins and non-coding RNA bindings. DNA methylation has become a new potential biomarker and therapy target.
