中国现代药物应用
中國現代藥物應用
중국현대약물응용
CHINESE JOURNAL OF MODERN DRUG APPLICATION
2014年
8期
34-35
,共2页
HPLC-EISD法%庆大霉素%面积归一化%含量
HPLC-EISD法%慶大黴素%麵積歸一化%含量
HPLC-EISD법%경대매소%면적귀일화%함량
HPLC-EISD method%Gentamicin%Normalized peak area technique%Content
目的:建立HPLC-ELSD面积归一化法测定硫酸庆大霉素含量的测定方法。方法色谱柱为Inertsil ODS-SP(4.6 mm×250 mm/5μm);流动相:0.2 mol/L的乙酸-甲醇(93:7);流速0.6 ml/min;柱温:30℃;蒸发光散射检测器Alltech 3300的飘移管温度为110℃;气体流速为2.6 L/min。结果硫酸庆大霉素各组分分离完全,用面积归一化法测定庆大霉素的含量。结论方法简便快速,准确度高,重现性好,可有效控制药品质量。
目的:建立HPLC-ELSD麵積歸一化法測定硫痠慶大黴素含量的測定方法。方法色譜柱為Inertsil ODS-SP(4.6 mm×250 mm/5μm);流動相:0.2 mol/L的乙痠-甲醇(93:7);流速0.6 ml/min;柱溫:30℃;蒸髮光散射檢測器Alltech 3300的飄移管溫度為110℃;氣體流速為2.6 L/min。結果硫痠慶大黴素各組分分離完全,用麵積歸一化法測定慶大黴素的含量。結論方法簡便快速,準確度高,重現性好,可有效控製藥品質量。
목적:건립HPLC-ELSD면적귀일화법측정류산경대매소함량적측정방법。방법색보주위Inertsil ODS-SP(4.6 mm×250 mm/5μm);류동상:0.2 mol/L적을산-갑순(93:7);류속0.6 ml/min;주온:30℃;증발광산사검측기Alltech 3300적표이관온도위110℃;기체류속위2.6 L/min。결과류산경대매소각조분분리완전,용면적귀일화법측정경대매소적함량。결론방법간편쾌속,준학도고,중현성호,가유효공제약품질량。
Objective To establish a method for the determination of gentamicin sulfate content by HPLC-ELSD method.Methods A C18 column was used, the mobile was 0.2mol/L Acetic Acid-methanol(93:7), the flow was 0.6ml/min the detecter was ELSD .The temperature of drift was 110℃ and flow rate of carrier gas was 2.6 L/min. Ruslts The gentamicin sulfate was sperated from its related substance completely.The Norm of peak area technique could be used to determine the gentamicin sulfate.Conclusion The method is simple and convenient, accurate, sensible an reproducible. This method is suitable for the quality control of the gentamicin sulfate.