CAJ | 학술논문

目的探讨临床因素、剂量体积参数与≥2级放射性肺炎（RP）的相关性。方法入组我院行放射治疗或联合化疗的85例非小细胞肺癌患者资料，回顾分析临床因素[患者年龄、性别、Karnofsky评分、化疗因素、肿瘤位置、第一秒用力呼气量(FEV1.0)、用力肺活量（FVC）]以及肺剂量体积参数[包括双肺接受5～60Gy的相对肺体积（V5-60）、平均肺剂量（MLD）、正常组织并发症概率（NTCP）]与≥2级RP的相关性。结果入组患者中位放疗剂量60Gy，中位随访时间12个月，累计有17例(20.0%)患者发生≥2级RP，3例（3.5%）发生3级RP，1例女性患者死于5级RP。结论肺功能和剂量体积参数均与RP的发生风险相关，MLD与RP最相关。
목적탐토림상인소、제량체적삼수여≥2급방사성폐염（RP）적상관성。방법입조아원행방사치료혹연합화료적85례비소세포폐암환자자료，회고분석림상인소[환자년령、성별、Karnofsky평분、화료인소、종류위치、제일초용력호기량(FEV1.0)、용력폐활량（FVC）]이급폐제량체적삼수[포괄쌍폐접수5～60Gy적상대폐체적（V5-60）、평균폐제량（MLD）、정상조직병발증개솔（NTCP）]여≥2급RP적상관성。결과입조환자중위방료제량60Gy，중위수방시간12개월，루계유17례(20.0%)환자발생≥2급RP，3례（3.5%）발생3급RP，1례녀성환자사우5급RP。결론폐공능화제량체적삼수균여RP적발생풍험상관，MLD여RP최상관。
Purpose To determine a serial of clinical factors and dose-volume parameters correlated with pneumonitis in non-small cell lung cancer (NSCLC) patients treated with radiochemotherapy.Methods Eight-ifve patients with locally advanced stage NSCLC patients undergoing radiotherapy with or without chemotherapy were enrolled. Clinical factors [e.g. age, gender, Karnofsky, chemotherapy, tumor location, forced expiratory volume at 1st (FEV1.0), forced volume capacity (FVC)] and dose-volume parameters [percentage of total lung volume exceeding 5~60 Gy (V5-60), mean lung dose (MLD), and normal tissue complication probability (NTCP)] were correlated with radiation pneumonitis (RP) by independent sample t test, chi-square, and logistic regression.Results With a median radiation dose of 60Gy and a median follow-up time of 12 months, 17 cases (20. 0%) of G2 or worse RP were observed, of which 3 cases (3.5%) were G3 and one female patient died of G5 RP. Conclusions Pulmonary function and dose-volume parameters were coorelation with the development of RP, among which MLD was an independent risk factor.