CAJ | 학술논문

综述了模式识别受体（Pattern recognition receptors，PRRs）及其相关分子佐剂的研究进展。PRRs是一类表达于固有免疫细胞并可识别病原体相关分子模式的识别分子。PRRs主要包括Toll样受体、NOD样受体、RIG—I样受体、清道夫受体、甘露糖受体和髓系细胞触发受体等。与PRRs直接相关的分子佐剂主要包括TLR激动剂、NLR激动剂、RIG—I和MDA5激动剂及CD40和肿瘤坏死因子受体超家族（TNFRSF）激动剂等。
종술료모식식별수체（Pattern recognition receptors，PRRs）급기상관분자좌제적연구진전。PRRs시일류표체우고유면역세포병가식별병원체상관분자모식적식별분자。PRRs주요포괄Toll양수체、NOD양수체、RIG—I양수체、청도부수체、감로당수체화수계세포촉발수체등。여PRRs직접상관적분자좌제주요포괄TLR격동제、NLR격동제、RIG—I화MDA5격동제급CD40화종류배사인자수체초가족（TNFRSF）격동제등。
In this paper, the developments of PRRs and its relevant molecular adjuvants were reviewed. PRRs were a kind of recognition molecules expressed on innate immune cells that can recognize pathogen - associated molecular patterns (PAMPs). PRRs mainly included Toll- like receptors (TLRs), NOD -like receptors (NLRs), RIG- I like receptors (RLRs), scavenger receptors (SRs), mannose receptors (MRs) and triggering receptors expressed on myeloid cells (TREMs), etc. Molecular adjuvants directly related to PRRs mainly including TLR agonists, NLR agonists, RIG - I & MDA5 agonists and CD40 & tumor necrosis factor receptor of superfamily (TNFRSF) agonists, etc.