中西医结合心脑血管病杂志
中西醫結閤心腦血管病雜誌
중서의결합심뇌혈관병잡지
CHINESE JOURNAL OF INTEGRATIVE MEDICINE ON CARDIO-/CEREBROVASCULAR DISEASE
2014年
4期
395-398
,共4页
短暂脑缺血发作%脑脉泰胶囊%阿司匹林%症状积分
短暫腦缺血髮作%腦脈泰膠囊%阿司匹林%癥狀積分
단잠뇌결혈발작%뇌맥태효낭%아사필림%증상적분
transient ischemic attack%Naomaitai capsule%aspirin%scores of syrnptom
目的：评价脑脉泰胶囊对短暂性脑缺血发作(TIA)病人的治疗作用,探索中药治疗 TIA 的方法。方法采用随机、双盲双模拟、1∶1∶1对照、单中心探索性研究,将108例病人分为3组：脑脉泰组、脑脉泰+阿司匹林组、阿司匹林组,每组36例,最终完成103例,脱落5例。观察3组治疗前后症状积分变化及临床疗效。结果脑脉泰组临床痊愈率、显效率、有效率、无效率分别为20.59%、8.82%、64.71%、5.88%,合并有效率为94.12%；脑脉泰+阿司匹林组临床痊愈率、显效率、有效率、无效率分别为8.57%、37.14%、51.43%、2.86%,合并有效率为97.14%；阿司匹林组临床痊愈率、显效率、有效率、无效率分别为11.76%、14.71%、50.00%、23.53%,合并总有效率为76.47%。3组有效率比较差异有统计学意义(P =0.0439),PP(符合方案集)分析与 ITT(意向性治疗原则)分析结果基本一致。结论脑脉泰囊胶囊治疗 TIA 安全有效。
目的：評價腦脈泰膠囊對短暫性腦缺血髮作(TIA)病人的治療作用,探索中藥治療 TIA 的方法。方法採用隨機、雙盲雙模擬、1∶1∶1對照、單中心探索性研究,將108例病人分為3組：腦脈泰組、腦脈泰+阿司匹林組、阿司匹林組,每組36例,最終完成103例,脫落5例。觀察3組治療前後癥狀積分變化及臨床療效。結果腦脈泰組臨床痊愈率、顯效率、有效率、無效率分彆為20.59%、8.82%、64.71%、5.88%,閤併有效率為94.12%；腦脈泰+阿司匹林組臨床痊愈率、顯效率、有效率、無效率分彆為8.57%、37.14%、51.43%、2.86%,閤併有效率為97.14%；阿司匹林組臨床痊愈率、顯效率、有效率、無效率分彆為11.76%、14.71%、50.00%、23.53%,閤併總有效率為76.47%。3組有效率比較差異有統計學意義(P =0.0439),PP(符閤方案集)分析與 ITT(意嚮性治療原則)分析結果基本一緻。結論腦脈泰囊膠囊治療 TIA 安全有效。
목적：평개뇌맥태효낭대단잠성뇌결혈발작(TIA)병인적치료작용,탐색중약치료 TIA 적방법。방법채용수궤、쌍맹쌍모의、1∶1∶1대조、단중심탐색성연구,장108례병인분위3조：뇌맥태조、뇌맥태+아사필림조、아사필림조,매조36례,최종완성103례,탈락5례。관찰3조치료전후증상적분변화급림상료효。결과뇌맥태조림상전유솔、현효솔、유효솔、무효솔분별위20.59%、8.82%、64.71%、5.88%,합병유효솔위94.12%；뇌맥태+아사필림조림상전유솔、현효솔、유효솔、무효솔분별위8.57%、37.14%、51.43%、2.86%,합병유효솔위97.14%；아사필림조림상전유솔、현효솔、유효솔、무효솔분별위11.76%、14.71%、50.00%、23.53%,합병총유효솔위76.47%。3조유효솔비교차이유통계학의의(P =0.0439),PP(부합방안집)분석여 ITT(의향성치료원칙)분석결과기본일치。결론뇌맥태낭효낭치료 TIA 안전유효。
Objective To evaluate the effect of Naomaitai capsule(NMTC)on patients of transient ischemic attack (TIA),and to discover the traditional Chinese medicine(TCM)method on TIA.Methods A random,double blind,double simulated,and 1∶1∶1 compared and single center discovery study was adopted.One hundred and eight patients were divided into three groups:NMTC group,NMTC plus aspirin group,aspirin group.Each group has 36 cases.At last,103 cases finished the study,5 cases lost.To observe the change of symptom after treatment of three groups.Results The clinical recovery ratio was 20.59%,remarkable effective ratio was 8.82%,effective ratio was 64.71%,invalid ratio was 5.88%,and total effective ratio was 94.12% in NMTC group.The clinical recovery ratio was 8.57%,remarkable effective ratio was 37.14%,effective ratio was 5 1.43%,invalid ratio was 2.86%,and total ef-fective ratio was 97.14% in NMTC plus aspirin group.The clinical recovery ratio was 1 1.76%,remarkable effective ratio was 14.71%, effective ratio was 50.00%,invalid ratio was 23.53%,and total effective ratio was 76.47% in aspirin group.The effective ratio of the three group had remarkable different (P =0.043 9).Analysis PP and ITT had the same result.Conclusion NMTC can improve the prognosis and symptom of TIA safely.
