CAJ | 학술논문

目的：考查离子导入对阿魏酸透皮吸收的影响。方法采用小鼠腹部皮肤，以阿魏酸溶液为供体溶液，采用改良Franz 扩散池，用紫外分光光度法测定受体池中药物含量，考察10 h 内是否施加离子导入对阿魏酸透皮吸收的影响。结果离子导入明显促进体外模型中阿魏酸的皮肤透过量。结论离子导入能促进阿魏酸的透皮吸收，为中药其他有机酸成分的透皮吸收提供了实验依据。
목적：고사리자도입대아위산투피흡수적영향。방법채용소서복부피부，이아위산용액위공체용액，채용개량Franz 확산지，용자외분광광도법측정수체지중약물함량，고찰10 h 내시부시가리자도입대아위산투피흡수적영향。결과리자도입명현촉진체외모형중아위산적피부투과량。결론리자도입능촉진아위산적투피흡수，위중약기타유궤산성분적투피흡수제공료실험의거。
Objective To evaluate the improvement of iontophoresis on the transdermal permeation of ferulic acid. Methods The abdominal skin of mice was inserted in the modified Franz diffusion cell. Ferulic acid solution was the donor. The content of drug in the acceptor was quantified using the ultraviolet spectrophotometry. The influence of iontophoresis on permeation of ferulic acid was investigated within 10 hours. Results The transdermal amount of ferulic acid was significantly improved by iontophoresis in vitro. Conclusion Iontophoresis significantly improved ferulic acid permeation across skin. It could be a successful method to promote the skin permeation of other organic acids in traditional Chinese medicines.