CAJ | 학술논문

目的：探讨调强放疗联合替吉奥治疗未手术老年食管癌的近期疗效。方法回顾60例未手术老年食管癌患者资料，以单纯采用调强放疗治疗的30例患者为对照组，剂量模式为60～63 Gy/30次/6周，试验组30例则在此基础上同期口服替吉奥。比较2组临床疗效，免疫功能指标IgG、IgM、IgA变化情况，不良反应和2年生存率。结果试验组总有效率为86．7％，对照组为63．3％，差异具有统计学意义（P＜0．05）；免疫功能指标IgG、IgM、IgA治疗前后变化具有统计学意义（P＜0．05）；不良反应未见明显差异；1年生存率未见明显差异，18个月和2年生存率差异具有统计学意义。结论调强放疗联合替吉奥治疗未手术老年食管癌的近期疗效肯定，不良反应可耐受。
목적：탐토조강방료연합체길오치료미수술노년식관암적근기료효。방법회고60례미수술노년식관암환자자료，이단순채용조강방료치료적30례환자위대조조，제량모식위60～63 Gy/30차/6주，시험조30례칙재차기출상동기구복체길오。비교2조림상료효，면역공능지표IgG、IgM、IgA변화정황，불량반응화2년생존솔。결과시험조총유효솔위86．7％，대조조위63．3％，차이구유통계학의의（P＜0．05）；면역공능지표IgG、IgM、IgA치료전후변화구유통계학의의（P＜0．05）；불량반응미견명현차이；1년생존솔미견명현차이，18개월화2년생존솔차이구유통계학의의。결론조강방료연합체길오치료미수술노년식관암적근기료효긍정，불량반응가내수。
Objective To investigate the short-term effect of intensity modulated radiotherapy treatment ( IMRT) com-bined with Tegafur Gimeracil Oteracil Potassium in the treatment of non-surgical elderly patients with esophageal cancer .Methods The data of 60 non-surgical elderly patients with esophageal cancer were retrospectively analyzed .30 patients underwent IMRT were the control group ,with the dose of 60~63 Gy/30 times/6 weeks.30 patients in the experiment group received additional oral administration of Tegafur Gimeracil Oteracil Potassium .The clinical efficacy ,changes of immune function indicators IgG ,IgM and IgA,adverse reactions ,and 2-year survival rates were compared .Results The total effective rate was 86.7% in the experiment group and 63.3%in the control group;the difference was statistically significant (P<0.05).The changes of immune function in-dicators IgG,IgM and IgA were significantly different before and after treatment (P<0.05).There was no significant difference in adverse reactions.The 1-year survival rate was not significantly different ,but 18-month and 2-year survival rates were signifi-cantly different .Conclusion IMRT combined with Tegafur Gimeracil Oteracil Potassium has a considerable effect and tolerable adverse reactions in the treatment of non-surgical elderly patients with esophageal cancer .