CAJ | 학술논문

目的：探讨高频超声在兔股动脉狭窄的应用价值。方法24只新西兰兔随机分为三组，每组8只，制备兔股动脉硬化模型：股动脉球囊损伤后分别高脂喂养4周、8周、12周，取耳缘静脉血检测胆固醇水平的变化，采用18 MHz 超高频超声探头观察股动脉的狭窄情况，测量造模处直径狭窄率、收缩期峰值血流速度（PSV），病理检测动脉管腔的面积狭窄率。结果（1）随着高脂喂养时间的延长，血中胆固醇水平递增，组间比较差异具有统计学意义（P ＜0.001）。（2）与造模前（0周）相比较，高脂喂养4周、8周、12周时股动脉造模处出现不同程度的狭窄，狭窄程度随时间延长逐渐增加，组间两两比较差异具有统计学意义（P ＜0.05）；狭窄处收缩期血流峰值流速随着狭窄程度的增加而加快，组间比较具有统计学意义（P ＜0.001）。（3）随着高脂喂养时间的延长，病理组织的面积狭窄率增加，组间比较均具有统计学差异（P ＜0.05）。结论（1）高脂喂养加球囊损伤能造成不同程度的兔股动脉狭窄；（2）超高频超声能够清晰地显示不同程度的兔股动脉狭窄，可用于动物外周血管疾病模型的检测。
목적：탐토고빈초성재토고동맥협착적응용개치。방법24지신서란토수궤분위삼조，매조8지，제비토고동맥경화모형：고동맥구낭손상후분별고지위양4주、8주、12주，취이연정맥혈검측담고순수평적변화，채용18 MHz 초고빈초성탐두관찰고동맥적협착정황，측량조모처직경협착솔、수축기봉치혈류속도（PSV），병리검측동맥관강적면적협착솔。결과（1）수착고지위양시간적연장，혈중담고순수평체증，조간비교차이구유통계학의의（P ＜0.001）。（2）여조모전（0주）상비교，고지위양4주、8주、12주시고동맥조모처출현불동정도적협착，협착정도수시간연장축점증가，조간량량비교차이구유통계학의의（P ＜0.05）；협착처수축기혈류봉치류속수착협착정도적증가이가쾌，조간비교구유통계학의의（P ＜0.001）。（3）수착고지위양시간적연장，병리조직적면적협착솔증가，조간비교균구유통계학차이（P ＜0.05）。결론（1）고지위양가구낭손상능조성불동정도적토고동맥협착；（2）초고빈초성능구청석지현시불동정도적토고동맥협착，가용우동물외주혈관질병모형적검측。
Objective To explore the application value of ultra -high frequency ultrasound in detection of femoral artery stenosis in rabbits.Methods Twenty-four healthy male New Zealand white rabbits (body weight 2.5 -3.0 kg) were randomly divided into three groups , 8 rabbits in each group.Preparation of femoral atherosclerosis model : the rabbits were fed with high fat diet for 4 weeks, 8 weeks and 12 weeks after femoral artery balloon injury , respectively.The changes of cholesterol level were observed .We used ultra-high frequency ultrasonic probe to observe the femoral artery , to assess the diameter stenosis rate and peak systolic velocity (SPV) at the symptomatic side, and the histological areal stenosis was evaluated.Results 1.The blood cholesterol levels were increased after fed high cholesterol diet , with a significant difference among the groups (P <0.001); 2.There was a stenosis to a different degree in the modeling artery after fed high cholesterol diet for 4 wks, 8 wks, and 12 wks, and the stenosis degree was increased gradually .At 12 w, the degree of stenosis was higher than that at 4 w and 8 w, respectively, showing statistical significance ( P <0.001).At the symptomatic side, the peak systolic flow velocity was increased , and it was higher at 12 w than that at 4w and 8 w, respectively.3.With the extension of time, the arterial stenosis rate was increased along with the time course (P <0.05). Conclusions 1.High fat diet combined with balloon injury can cause varying degrees of rabbit femoral artery stenosis ; 2. Ultrahigh frequency ultrasound can clearly show different degrees of rabbit femoral artery stenosis , and can be used for detecting the lesions in animal models of peripheral vascular diseases .