CAJ | 학술논문

目的：研究四逆散冻干粉及其拆方对睡眠影响的等效性研究。方法用四逆散冻干粉与其拆方对阈剂量戊巴比妥钠致小鼠睡眠时间影响，研究其对睡眠的影响。结果四逆散冻干粉与其拆方可明显延长戊巴比妥钠所致小鼠睡眠时间，与空白组比较，差异有统计学意义（ P＜0.01）。四逆散整方组明显优于其拆方组（ P＞0.01）。结论四逆散冻干粉与其拆方在延长阈剂量戊巴比妥钠所致小鼠睡眠时间上确实有效，且实验重现性较好。
목적：연구사역산동간분급기탁방대수면영향적등효성연구。방법용사역산동간분여기탁방대역제량무파비타납치소서수면시간영향，연구기대수면적영향。결과사역산동간분여기탁방가명현연장무파비타납소치소서수면시간，여공백조비교，차이유통계학의의（ P＜0.01）。사역산정방조명현우우기탁방조（ P＞0.01）。결론사역산동간분여기탁방재연장역제량무파비타납소치소서수면시간상학실유효，차실험중현성교호。
Objective To study on the effects of freeze -dry powder of Si-Ni-San and its recipes on sleep time.Methods Freeze-dry pow-der of Si-Ni-San and its recipes were adopted to prolong the sleep time of mice induced by pentobarbital sodium , and then its effects on sleeping were investigated.Results Freeze-dry powder of Si -Ni -San and its recipes significantly prolonged the sleep time of mice induced by pentobarbi-tal sodium, and there was statistical difference when compared with blank group (P<0.01).The efficacy of freeze-dry powder of Si-Ni-San was better than its recipes.Conclusion Freeze-dry powder of Si -Ni -San and its recipes are effective to prolong the sleep time of mice induced by pentobarbital sodium , and the trial is reliable with good reproducibility.