CAJ | 학술논문

目的：探讨奥氮平联合多奈哌齐治疗脑器质性精神障碍的临床疗效和安全性。方法将82例脑器质性精神障碍患者随机分为两组，均接受脑器质性疾病常规治疗及口服奥氮平治疗，研究组在此基础上联合多奈哌齐治疗。于治疗前后采用简明精神病量表、阳性与阴性症状量表、日常生活能力量表评定临床疗效及不良反应。结果治疗后两组各量表评分均较治疗前显著降低（P＜0．01），研究组显著低于对照组（P＜0．01）；两组不良反应发生率比较差异无显著性（P＞0．05）。结论奥氮平联合多奈哌齐治疗脑器质性精神障碍临床疗效显著，安全性高，优于单用奥氮平治疗。
목적：탐토오담평연합다내고제치료뇌기질성정신장애적림상료효화안전성。방법장82례뇌기질성정신장애환자수궤분위량조，균접수뇌기질성질병상규치료급구복오담평치료，연구조재차기출상연합다내고제치료。우치료전후채용간명정신병량표、양성여음성증상량표、일상생활능역량표평정림상료효급불량반응。결과치료후량조각량표평분균교치료전현저강저（P＜0．01），연구조현저저우대조조（P＜0．01）；량조불량반응발생솔비교차이무현저성（P＞0．05）。결론오담평연합다내고제치료뇌기질성정신장애림상료효현저，안전성고，우우단용오담평치료。
Objective To explore the efficacy of olanzapine plus donepezil in the treatment of brain organic psychosis (BOP) .Methods Eighty-two BOP patients were randomly divided into 2 groups ,both groups received conventional therapy for brain organic disease and took orally olanzapine ,on this basis research group was plus donepezil .Efficacies and adverse reac-tions were assessed with the Brief Psychiatric Rating Scale (BPRS) ,Positive and Negative Syndrome Scale (PANSS) and Activities of Daily Living (ADL) before and after treatment .Results After treatment all scales scores lowered more significantly compared with pretreatment (P<0 .01) ,those were significantly lower in research than control group (P<0 .01);there were no significant group differences in incidence of adverse reactions (P>0 .05) .Conclusion Olanzapine plus donepezil has an evident effect and higher safety compared with single olanzapine in the treatment of brain organic psychosis .