CAJ | 학술논문

目的：探讨雌激素与绝经后妇女异丙酚靶控输注麻醉术后认知功能障碍的关系。方法：将术前无认知障碍的40例妇科恶性肿瘤患者进行术后3d、7d认知功能评价，按MMSE得分将患者分为认知功能正常组和认知功能障碍组，所有患者术前均采用异丙酚靶控输注麻醉方式，测定及对比术前、术后3d及术后7d患者的空腹血清雌二醇浓度。结果：术后3d、7d正常组与障碍组术前血清雌二醇水平相比较无统计学意义，P＞0．05；术后3d障碍组与正常组患者血清雌二醇分别为（51．9±12．6VS84．7±19．2），7d血清雌二醇水平为（57．4±12．6VS85．8±21．7），均 P＜0．05。结论：绝经后妇女异丙酚靶控输注麻醉术后认知功能障碍的发生可能与雌激素水平降低有关。
목적：탐토자격소여절경후부녀이병분파공수주마취술후인지공능장애적관계。방법：장술전무인지장애적40례부과악성종류환자진행술후3d、7d인지공능평개，안MMSE득분장환자분위인지공능정상조화인지공능장애조，소유환자술전균채용이병분파공수주마취방식，측정급대비술전、술후3d급술후7d환자적공복혈청자이순농도。결과：술후3d、7d정상조여장애조술전혈청자이순수평상비교무통계학의의，P＞0．05；술후3d장애조여정상조환자혈청자이순분별위（51．9±12．6VS84．7±19．2），7d혈청자이순수평위（57．4±12．6VS85．8±21．7），균 P＜0．05。결론：절경후부녀이병분파공수주마취술후인지공능장애적발생가능여자격소수평강저유관。
Objective :To explore the relationship of estrogen and postoperative cognitive dysfunction in postmenopaus-al women with propofol target-controlled infusion .Methods :40 gynecologic malignancies patients with preoperative cog-nitive impairment were evaluated cognitive function at Postoperative 3d ,7d ,all patients were divided into normal cogni-tive function and cognitive dysfunction group according to MMSE scores ,and were used of propofol target-controlled infusion ,Measured and compared serum estradiol concentration at Postoperative 3d ,7d and Preoperative by fasting ve-nous blood .Results:Serum estradiol levels in the normal group and disorder group at Postoperative 3d ,7d were no sig-nificantly differences ,P>0 .05 ,serum estradiol levels in the disorder group and normal group at Postoperative 3d were (51 .9 ± 12 .6 VS 84 .7 ± 19 .2) ,Postoperative 3d were(57 .4 ± 12 .6 VS 85 .8 ± 21 .7) ,it was no significantly differ-ences .Conclusion:Postmenopausal women with propofol target-controlled infusion may occur with the decreased levels of estrogen .