CAJ | 학술논문

成骨细胞分泌的骨钙素是反映成骨细胞活性的敏感而特异的指标.近年的研究还发现,骨钙素是骨骼内分泌功能的重要媒介.羧化不全骨钙素可以促进胰岛β细胞增殖和胰岛素分泌,降低血糖和血脂水平,表明骨钙素对能量代谢具有重要的调控作用,这一发现将为肥胖症和糖尿病等代谢性疾病的治疗提供新的思路.
성골세포분비적골개소시반영성골세포활성적민감이특이적지표.근년적연구환발현,골개소시골격내분비공능적중요매개.최화불전골개소가이촉진이도β세포증식화이도소분비,강저혈당화혈지수평,표명골개소대능량대사구유중요적조공작용,저일발현장위비반증화당뇨병등대사성질병적치료제공신적사로.
Osteocalcin (OC) secreted by osteoblasts is a sensitive and specific indicator of osteoblast activity.Recently,it has been found that osteocalcin serves as an important mediator of endocrine function.Undercarboxylated OC can promote insulin secretion and β-cell proliferation,and lower glucose and lipid levels,suggesting that osteocalcin might play a major role in the regulation of energy metabolism.These findings provide a new insight for the treatment of metabolic diseases such as obesity and diabetes.