CAJ | 학술논문

目的：探讨Bmi-1蛋白在胃癌组织中的表达及其与胃癌临床病理特征的关系。方法采用免疫组化ABC法检测98例胃癌和9例正常胃组织Bmi-1蛋白的表达。结果胃癌组织Bmi-1蛋白阳性率为75.5%，远高于正常胃组织中Bmi-1蛋白11.1%的阳性率，两组间差异有统计学意义（P约0.01）。结论 Bmi-1蛋白在胃癌组织中高表达，在细胞增殖、凋亡及癌变过程中有重要作用，此标记能客观表明胃癌的临床病理特征。
목적：탐토Bmi-1단백재위암조직중적표체급기여위암림상병리특정적관계。방법채용면역조화ABC법검측98례위암화9례정상위조직Bmi-1단백적표체。결과위암조직Bmi-1단백양성솔위75.5%，원고우정상위조직중Bmi-1단백11.1%적양성솔，량조간차이유통계학의의（P약0.01）。결론 Bmi-1단백재위암조직중고표체，재세포증식、조망급암변과정중유중요작용，차표기능객관표명위암적림상병리특정。
Objective To explore the expression of B-cell specific Moloney murine leukemia virus insertion site 1(Bmi-1)in gastric carcinoma(GC)tissue and its relationship with the clinicopathological features of GC. Methods Immunohistochemistry was used to detect the expression of Bmi-1 in 98 cases of GC and 9 cases of normal mu-cosa. Results The positive rate of Bmi-1 expression in GC cases was significantly higher than that in normal gastric mucosa(75.5% vs 11.1%, P<0.05). Conclusion High expression of Bmi-1 protein in GC may be involved in cell proliferation, apoptosis and cancerization. This marker can objectively indicate the clinicopathological charac-teristics of GC.