CAJ | 학술논문

核苷作为核酸的结构单元,参与了基因信息的保留、复制和转录的分子机制,在生物合成和控制过程中起十分重要的作用。目前,核苷类药物在抗肿瘤和抗病毒药物中占有很大的比例,新型核苷类衍生物的合成研究一直是研究热点之一,文章对糖基修饰的核苷类衍生物研究进展进行总结。
핵감작위핵산적결구단원,삼여료기인신식적보류、복제화전록적분자궤제,재생물합성화공제과정중기십분중요적작용。목전,핵감류약물재항종류화항병독약물중점유흔대적비례,신형핵감류연생물적합성연구일직시연구열점지일,문장대당기수식적핵감류연생물연구진전진행총결。
Nucleosides as nucleic acid structure unit,a gene involved in the information retention,replication and transcription of the molecular mechanisms,in the biosynthesis and control process plays a very important role.At present,the nucleoside drugs in antitumor and antiviral drugs account for a large proportion,novel nucleoside derivatives synthesis is one of research hotspots,the glycosyl modified nucleoside compounds research progress summary.