广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2012年
18期
49-51
,共3页
N-羧甲基戊脒%Pinner%工艺
N-羧甲基戊脒%Pinner%工藝
N-최갑기무미%Pinner%공예
methyl pentanimidate%Pinner%technology
N-羧甲基戊脒是重要的合成中间体,用改进的Pinner酸催化方法合成盐酸亚戊脒,获得了较合适的工艺条件。用甲醇钠的甲醇溶液中和盐酸亚戊脒,降低了中和温度的要求,简化了操作步骤,并取得了较高的反应收率（0.934）。
N-羧甲基戊脒是重要的閤成中間體,用改進的Pinner痠催化方法閤成鹽痠亞戊脒,穫得瞭較閤適的工藝條件。用甲醇鈉的甲醇溶液中和鹽痠亞戊脒,降低瞭中和溫度的要求,簡化瞭操作步驟,併取得瞭較高的反應收率（0.934）。
N-최갑기무미시중요적합성중간체,용개진적Pinner산최화방법합성염산아무미,획득료교합괄적공예조건。용갑순납적갑순용액중화염산아무미,강저료중화온도적요구,간화료조작보취,병취득료교고적반응수솔（0.934）。
Methyl pentanimidate was a key intermediate of chemical synthesis. It was synthesized from valeronitrile by Pinner reaction, neutralization by CH3ONa and amination. The suitable technology for synthesizing the target compound was investigated in detail. CH3ONa was substituded for NaOH to neutralize hydrochloride to get methyl pentanimidate. The synthesis route was simplified and obtained a higher yield of 0. 934.
