中南民族大学学报:自然科学版
中南民族大學學報:自然科學版
중남민족대학학보:자연과학판
Journal of South-Central University for Nationalities
2012年
3期
43-51
,共9页
活性氧%氧自由基%脂质过氧化%信号转导%双向生物学效应
活性氧%氧自由基%脂質過氧化%信號轉導%雙嚮生物學效應
활성양%양자유기%지질과양화%신호전도%쌍향생물학효응
reactive oxygen species%oxygen radicals%bidirectional biological effects
指出了活性氧(ROS)是普遍存在于有氧代谢中的产物,其化学性质极为活跃,有关ROS对人体的危害已逐渐得到公认.然而,越来越多的研究提示,一直被认为是人类疾病元凶的ROS对机体和细胞也有有益的一面.综述了ROS的研究进展,揭示了ROS通过调节离子通道、受体、酶以及转录因子的活性和改变细胞氧化还原状态,进而参与细胞的正常生理过程(细胞的增殖、分化和凋亡),从而讨论了ROS的双向生物学效应和机制.
指齣瞭活性氧(ROS)是普遍存在于有氧代謝中的產物,其化學性質極為活躍,有關ROS對人體的危害已逐漸得到公認.然而,越來越多的研究提示,一直被認為是人類疾病元兇的ROS對機體和細胞也有有益的一麵.綜述瞭ROS的研究進展,揭示瞭ROS通過調節離子通道、受體、酶以及轉錄因子的活性和改變細胞氧化還原狀態,進而參與細胞的正常生理過程(細胞的增殖、分化和凋亡),從而討論瞭ROS的雙嚮生物學效應和機製.
지출료활성양(ROS)시보편존재우유양대사중적산물,기화학성질겁위활약,유관ROS대인체적위해이축점득도공인.연이,월래월다적연구제시,일직피인위시인류질병원흉적ROS대궤체화세포야유유익적일면.종술료ROS적연구진전,게시료ROS통과조절리자통도、수체、매이급전록인자적활성화개변세포양화환원상태,진이삼여세포적정상생리과정(세포적증식、분화화조망),종이토론료ROS적쌍향생물학효응화궤제.
Reactive oxygen species (ROS) are the common products of aerobic metabolism, having extremely high chemical activity. The deleterious effects of ROS on human body have been well known. However there are more and more studies suggesting that ROS, considered as the major cause for human diseases, also has the beneficial effects. This paper has summarized the research progress to reveal that R0S involves in a variety of normal physiological activities such as cellular proliferation, differentiation and apoptosis by mediating the activities of ion channels, receptors, enzymes and transcription factors and regulating the cellular redox buffering capacity, and the bidirectional biological effects and mechanisms of ROS are discussed.