CAJ | 학술논문

血液流变性质具有重要的病理和生理意义。针对血液流变特性测量的便携化和自动化发展，本文提出了一种基于PDMS芯片的简化的血液流变性质检测方法，初步设计并制作出一种集压力检测系统，平层腔，图像测速系统于一体的双面沟道微流控PDMS芯片血液流变检测系统。本文工作主要包括：基于芯片流路流速和压力变化的流体粘度测驻方法推导；利刚娃微图像配准操作的PDMS双面结构模塑成型工艺进行测量芯片的制作；结合双光路显微图像测量和简化压力驱动进行的系统构建等。最后将此芯片应用于血液流变性质实验进行系统的功能性验证。
혈액류변성질구유중요적병리화생리의의。침대혈액류변특성측량적편휴화화자동화발전，본문제출료일충기우PDMS심편적간화적혈액류변성질검측방법，초보설계병제작출일충집압력검측계통，평층강，도상측속계통우일체적쌍면구도미류공PDMS심편혈액류변검측계통。본문공작주요포괄：기우심편류로류속화압력변화적류체점도측주방법추도；리강왜미도상배준조작적PDMS쌍면결구모소성형공예진행측량심편적제작；결합쌍광로현미도상측량화간화압력구동진행적계통구건등。최후장차심편응용우혈액류변성질실험진행계통적공능성험증。
Rheology properties have important pathological and physiological significance. According to the portable measurement of blood rheolngical properties and automation development, this thesis conunitted to a rheolngy properties analysis method based on PDMS chip. Designed a PDMS micro - fluidie chip which is included of pressure measurement system, smooth layer cavity and image speed detection system. This research includes: the measuring method of the viscosity relate to flow velocity and pressure; invented a doable - channel of PDMS molding method and we designed a micro - fluidic chip measurement system included many subsystem. Finally,we have experiments; the result proves the possibility of proposed design.