上海化工
上海化工
상해화공
SHANGHAI CHEMICAL INDUSTRY
2012年
9期
14-16
,共3页
张恩立%周鹏%李家明%何勇%袁明%许勤龙
張恩立%週鵬%李傢明%何勇%袁明%許勤龍
장은립%주붕%리가명%하용%원명%허근룡
咪唑%化学合成%抗血小板聚集
咪唑%化學閤成%抗血小闆聚集
미서%화학합성%항혈소판취집
Imidazole%Synthesis%Antiplatelet aggregation
以芳酸酯为起始原料,经Williamson醚化、亲核取代和水解反应,合成4-[2-羟基-3-（1H-咪唑基-1）丙氧基]-3-甲氧基苯甲酸及其3个类似物（3c~3f）。所合成的目标化合物均未见文献报道,其结构经IR、1H-NMR、13C-NMR及MS确证。所设计的合成方法简单易行。
以芳痠酯為起始原料,經Williamson醚化、親覈取代和水解反應,閤成4-[2-羥基-3-（1H-咪唑基-1）丙氧基]-3-甲氧基苯甲痠及其3箇類似物（3c~3f）。所閤成的目標化閤物均未見文獻報道,其結構經IR、1H-NMR、13C-NMR及MS確證。所設計的閤成方法簡單易行。
이방산지위기시원료,경Williamson미화、친핵취대화수해반응,합성4-[2-간기-3-（1H-미서기-1）병양기]-3-갑양기분갑산급기3개유사물（3c~3f）。소합성적목표화합물균미견문헌보도,기결구경IR、1H-NMR、13C-NMR급MS학증。소설계적합성방법간단역행。
The 4-(2-hydmxy-3-(1H-imidazol-1-yl) propoxy)-3-methoxy benzoic acid and its analogues (3c-3f) were synthesized from aryl esters via Williamson etherification, nucleophilic Substitution and hydroxylation. The target eompounds synthesized had not been reported in literatures, and their Chemical structures were confirmed by IR, 1H-NMR, 13C-NMR and MS. The results showed that the synthetic method was simple and feasible.
