中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2013年
5期
510-512
,共3页
邓捷%朱亦堃%史书红%李兴%赵宝珍
鄧捷%硃亦堃%史書紅%李興%趙寶珍
산첩%주역곤%사서홍%리흥%조보진
糖尿病2型%骨钙素
糖尿病2型%骨鈣素
당뇨병2형%골개소
Diabetes mellitus,type 2%Osteocalcin
目的 研究老年2型糖尿病患者血糖、胰岛素、胰岛素抵抗指数、骨密度与骨钙素的相关性. 方法 选择55例2型糖尿病患者和50例非糖尿病对照者,年龄均≥60岁,比较两组间的空腹血糖(FBG)、糖化血红蛋白(HbAlc)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、骨钙素、体质指数(BMI),骨密度,分析血清骨钙素水平与各项指标的相关性. 结果 对照组的骨钙素[(11.2±3.2) μg/L比(4.1±3.0)μg/L]、骨密度(-1.3±0.3比-2.6±0.5)高于老年2型糖尿病组,空腹血糖[(4.7±2.0) mmol/L比(9.4±2.1) mmol/L]、糖化血红蛋白[(4.8±1.5)％比(7.6±1.6)％]、胰岛素[(7.4±3.2) U/L比(23.7±3.0) U/L]、胰岛素抵抗指数(1.5±0.7比9.9±1.2)低于老年2型糖尿病组(P＜0.05).骨钙素与老年2型糖尿病患者的FBG、HbAlc、FINS、HOMA-IR呈负相关(r=-0.739、-0.713、-0.613、-0.092,均P＜0.05),骨钙素与骨密度呈正相关(r=0.269,P＜0.05). 结论 血清骨钙素水平与老年2型糖尿病患者的血糖水平及胰岛素抵抗程度相关.
目的 研究老年2型糖尿病患者血糖、胰島素、胰島素牴抗指數、骨密度與骨鈣素的相關性. 方法 選擇55例2型糖尿病患者和50例非糖尿病對照者,年齡均≥60歲,比較兩組間的空腹血糖(FBG)、糖化血紅蛋白(HbAlc)、空腹胰島素(FINS)、胰島素牴抗指數(HOMA-IR)、骨鈣素、體質指數(BMI),骨密度,分析血清骨鈣素水平與各項指標的相關性. 結果 對照組的骨鈣素[(11.2±3.2) μg/L比(4.1±3.0)μg/L]、骨密度(-1.3±0.3比-2.6±0.5)高于老年2型糖尿病組,空腹血糖[(4.7±2.0) mmol/L比(9.4±2.1) mmol/L]、糖化血紅蛋白[(4.8±1.5)％比(7.6±1.6)％]、胰島素[(7.4±3.2) U/L比(23.7±3.0) U/L]、胰島素牴抗指數(1.5±0.7比9.9±1.2)低于老年2型糖尿病組(P＜0.05).骨鈣素與老年2型糖尿病患者的FBG、HbAlc、FINS、HOMA-IR呈負相關(r=-0.739、-0.713、-0.613、-0.092,均P＜0.05),骨鈣素與骨密度呈正相關(r=0.269,P＜0.05). 結論 血清骨鈣素水平與老年2型糖尿病患者的血糖水平及胰島素牴抗程度相關.
목적 연구노년2형당뇨병환자혈당、이도소、이도소저항지수、골밀도여골개소적상관성. 방법 선택55례2형당뇨병환자화50례비당뇨병대조자,년령균≥60세,비교량조간적공복혈당(FBG)、당화혈홍단백(HbAlc)、공복이도소(FINS)、이도소저항지수(HOMA-IR)、골개소、체질지수(BMI),골밀도,분석혈청골개소수평여각항지표적상관성. 결과 대조조적골개소[(11.2±3.2) μg/L비(4.1±3.0)μg/L]、골밀도(-1.3±0.3비-2.6±0.5)고우노년2형당뇨병조,공복혈당[(4.7±2.0) mmol/L비(9.4±2.1) mmol/L]、당화혈홍단백[(4.8±1.5)％비(7.6±1.6)％]、이도소[(7.4±3.2) U/L비(23.7±3.0) U/L]、이도소저항지수(1.5±0.7비9.9±1.2)저우노년2형당뇨병조(P＜0.05).골개소여노년2형당뇨병환자적FBG、HbAlc、FINS、HOMA-IR정부상관(r=-0.739、-0.713、-0.613、-0.092,균P＜0.05),골개소여골밀도정정상관(r=0.269,P＜0.05). 결론 혈청골개소수평여노년2형당뇨병환자적혈당수평급이도소저항정도상관.
Objective To investigate the correlation between serum osteocalcin and type 2 diabetes mellitus (T2DM) in elderly patients.Methods A total of 55 T2DM patients (diabetic group) and 50 non-diabetic subjects (control group) aged ≥60 years were enrolled in this study.The levels of fasting blood glucose (FBG),glycated hemoglobin (HbAlc),insulin resistance index (HOMA IR),osteocalcin (OC),body mass index (BMI) and bone mineral density (BMD) in groups were compared.The correlations between serum osteocalcin and the above indicators were analyzed.Results The levels of OC and BMD were higher in control group than in diabetic group [(11.2±3.2)μg/Lvs.(4.1±3.0)μg/L,(-1.3±0.3) vs.(-2.6±0.5),respectively,both P＜0.05].The levels of FBG,HbAlc,FINS,HOMA-IR were lower in control group than in diabetic group [(4.7±2.0) mmol/L vs.(9.4±2.1) mmol/L],[(4.8±1.5) ％ vs.(7.6±1.6)％,(7.4±3.2) U/L vs.(23.7±3.0) U/L,(1.5±0.7) vs.(9.9±1.2),respectively,all P＜0.05].Serum osteocalcin concentration was negatively correlated with the levels of FBG,HbAlc,FINS and HOMA-IR in elderly patients with T2DM (r=-0.739,-0.713,-0.613,-0.092,all P＜0.01).Conclusions Serum osteocalcin concentration is correlated with the levels of blood sugar and insulin resistance index in elderly patients with T2DM.A further study on the correlation between osteocalcin and T2DM may provide a new target for the treatment of type 2 diabetes mellitus.
