CAJ | 학술논문

目的：观察丹参酮IIA磺酸钠注射液（STS）治疗晚期血吸虫病（晚血）临床效果。方法选择2012-011-2013-11入住东台市头灶中心卫生院的晚血患者50例，予以STS治疗10 d，治疗前、后进行门静脉内径、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、γ-谷氨酰转肽酶（γ-GT）、Ⅲ型前胶原肽、Ⅳ型胶原、层黏蛋白、透明质酸（HA）检测。结果治疗前血清学检测指标的均值除HA高于正常外，余均正常；指标异常患者数最高分别为γ-GT（26.0%）及HA（54.0%）。治疗后各项指标均值和指标异常患者数均有所下降，但HA的均值仍高于正常。门静脉内径由治前的（10.5±1.7）mm降至治后的（9.8±1.3） mm，改善明显。结论 STS对晚血病人的治疗具有一定的效果，适合于基层单位使用。
목적：관찰단삼동IIA광산납주사액（STS）치료만기혈흡충병（만혈）림상효과。방법선택2012-011-2013-11입주동태시두조중심위생원적만혈환자50례，여이STS치료10 d，치료전、후진행문정맥내경、병안산안기전이매、천동안산안기전이매、γ-곡안선전태매（γ-GT）、Ⅲ형전효원태、Ⅳ형효원、층점단백、투명질산（HA）검측。결과치료전혈청학검측지표적균치제HA고우정상외，여균정상；지표이상환자수최고분별위γ-GT（26.0%）급HA（54.0%）。치료후각항지표균치화지표이상환자수균유소하강，단HA적균치잉고우정상。문정맥내경유치전적（10.5±1.7）mm강지치후적（9.8±1.3） mm，개선명현。결론 STS대만혈병인적치료구유일정적효과，괄합우기층단위사용。
Objective To evaluate the clinical efficacy of sodium tanshinone IIA sulfonate(STS)in the treatment of ad-vanced schistosomiasis. Methods Fifty cases with advanced schistosomiasis admitted to the Touzao Township Hospital of Dong-tai City during the period from November 2012 to November 2013 were treated with STS for 10 days,and the internal diameter of the portal vein,levels of ALT,AST,γ-GT,PIIIP,CIV,HA and LN were measured and compared before and after the adminis-tration of STS. Results The mean levels of all serological parameters except HA were within the normal range before STS treat-ment,while the highest positive rate was detected inγ-GT(26.0%)and HA(54.0%). Following the STS treatment,the mean lev-els of all parameters and the positive rates reduced,with the greatest reduction observed inγ-GT(36.7%)and HA(37.8%);how-ever,the mean HA level was still higher than the normal range. The mean internal diameter of the portal vein reduced from(10.5± 1.7)mm before the STS treatment to(9.8±1.3)mm after the STS administration,with a significant diffrtence(P<0.05). Conclu-sion STS appears effective in the treatment of advanced schistosomiasis.