波谱学杂志
波譜學雜誌
파보학잡지
CHINESE JOURNAL OF MAGNETIC RESONANCE
2014年
2期
253-261
,共9页
核磁共振(NMR)%氮杂双环%1D NOESY%选择性远程DEPT%立体化学
覈磁共振(NMR)%氮雜雙環%1D NOESY%選擇性遠程DEPT%立體化學
핵자공진(NMR)%담잡쌍배%1D NOESY%선택성원정DEPT%입체화학
NMR%azabicyclo-type compound%1D NOESY%selective long-range DEPT%stereochemistry
该文基于2-苯基-2-环戊基-2-羟基乙酸-3-甲基-3-氮杂双环(3,3,1)壬-9α-酯,对氮杂双环型化合物的立体化学结构的NMR测定方法进行了研究。结果表明,采用选择性远程DEPT与多频率位移选择激发一维(1D)NOESY相结合的方法,可有效解决该类化合物NMR谱的碳信号归属困难的问题,同时有助于构型和立体结构的测定。该方法对于准确阐明氮杂双环型化合物的化学结构和立体化学特征具有较好的指导意义。
該文基于2-苯基-2-環戊基-2-羥基乙痠-3-甲基-3-氮雜雙環(3,3,1)壬-9α-酯,對氮雜雙環型化閤物的立體化學結構的NMR測定方法進行瞭研究。結果錶明,採用選擇性遠程DEPT與多頻率位移選擇激髮一維(1D)NOESY相結閤的方法,可有效解決該類化閤物NMR譜的碳信號歸屬睏難的問題,同時有助于構型和立體結構的測定。該方法對于準確闡明氮雜雙環型化閤物的化學結構和立體化學特徵具有較好的指導意義。
해문기우2-분기-2-배무기-2-간기을산-3-갑기-3-담잡쌍배(3,3,1)임-9α-지,대담잡쌍배형화합물적입체화학결구적NMR측정방법진행료연구。결과표명,채용선택성원정DEPT여다빈솔위이선택격발일유(1D)NOESY상결합적방법,가유효해결해류화합물NMR보적탄신호귀속곤난적문제,동시유조우구형화입체결구적측정。해방법대우준학천명담잡쌍배형화합물적화학결구화입체화학특정구유교호적지도의의。
We present an NMR method for determining stereochemical structure of azabicyclo-type compounds, with 2-pheny-2-cycloamyl-2-hydroxyacetic-N-methly-3 azabiclo [3, 3, 1] nonane-9-carboxylate as the example. We showed that the carbon NMR spectra of azabicyclo-type compounds can be assigned effectively using the combination of multiple-frequency selective excitation double pulsed field gradient spin echo 1D NOESY and selective long-range DEPT, providing valuable information for conformation and stereo structure determination. The method presented is of significant value for studying the stereochemical characteristics and structures of azabicyclo-type compounds.