中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
12期
1568-1569
,共2页
深静脉血栓%疏血通注射液%胫骨骨折
深靜脈血栓%疏血通註射液%脛骨骨摺
심정맥혈전%소혈통주사액%경골골절
Deep venous thrombosis%Shuxuetong injection%Tibial fractures
目的 观察疏血通注射液预防胫骨骨折髓内钉内固定术后下肢深静脉血栓(DVT)形成的疗效.方法 将89例患者按就诊顺序随机分为研究组(43例)和对照组(46例),研究组于术后第1天给6ml加入5％葡萄糖或9％氯化钠注射液250 ml中静脉滴注,1次/d.对照组术后12 h起使用低分子肝素钙4000 U皮下注射,1次/d,2组疗程均为7d.对照组予低分子肝素钙常规抗凝;研究组采用疏血通注射液行中药抗凝.术后第14天行下肢血栓B超检查,观察DVT的发生率.结果 术后第14天,研究组DVT发生率低于对照组[11.6％(5例)比13.0％(6例)],但差异无统计学意义(P＞0.05).研究组日平均抗凝费用低于对照组[(73.3±9.1)元比(149.3 ±14.5)元],差异有统计学意义(P＜0.05).研究组治疗前、术后第3天、术后第14天内皮素分别为(30±9)、(80±9)、(45±9)ng/L,对照组分别为(32±9)、(83±9)、(52±9) ng/L,2组术后第14天内皮素水平明显低于术后第3天,研究组明显低于对照组,差异均有统计学意义(均P ＜0.05).结论 疏血通注射液能有效预防胫骨髓内钉术后DVT的发生,且治疗费用更低廉.
目的 觀察疏血通註射液預防脛骨骨摺髓內釘內固定術後下肢深靜脈血栓(DVT)形成的療效.方法 將89例患者按就診順序隨機分為研究組(43例)和對照組(46例),研究組于術後第1天給6ml加入5％葡萄糖或9％氯化鈉註射液250 ml中靜脈滴註,1次/d.對照組術後12 h起使用低分子肝素鈣4000 U皮下註射,1次/d,2組療程均為7d.對照組予低分子肝素鈣常規抗凝;研究組採用疏血通註射液行中藥抗凝.術後第14天行下肢血栓B超檢查,觀察DVT的髮生率.結果 術後第14天,研究組DVT髮生率低于對照組[11.6％(5例)比13.0％(6例)],但差異無統計學意義(P＞0.05).研究組日平均抗凝費用低于對照組[(73.3±9.1)元比(149.3 ±14.5)元],差異有統計學意義(P＜0.05).研究組治療前、術後第3天、術後第14天內皮素分彆為(30±9)、(80±9)、(45±9)ng/L,對照組分彆為(32±9)、(83±9)、(52±9) ng/L,2組術後第14天內皮素水平明顯低于術後第3天,研究組明顯低于對照組,差異均有統計學意義(均P ＜0.05).結論 疏血通註射液能有效預防脛骨髓內釘術後DVT的髮生,且治療費用更低廉.
목적 관찰소혈통주사액예방경골골절수내정내고정술후하지심정맥혈전(DVT)형성적료효.방법 장89례환자안취진순서수궤분위연구조(43례)화대조조(46례),연구조우술후제1천급6ml가입5％포도당혹9％록화납주사액250 ml중정맥적주,1차/d.대조조술후12 h기사용저분자간소개4000 U피하주사,1차/d,2조료정균위7d.대조조여저분자간소개상규항응;연구조채용소혈통주사액행중약항응.술후제14천행하지혈전B초검사,관찰DVT적발생솔.결과 술후제14천,연구조DVT발생솔저우대조조[11.6％(5례)비13.0％(6례)],단차이무통계학의의(P＞0.05).연구조일평균항응비용저우대조조[(73.3±9.1)원비(149.3 ±14.5)원],차이유통계학의의(P＜0.05).연구조치료전、술후제3천、술후제14천내피소분별위(30±9)、(80±9)、(45±9)ng/L,대조조분별위(32±9)、(83±9)、(52±9) ng/L,2조술후제14천내피소수평명현저우술후제3천,연구조명현저우대조조,차이균유통계학의의(균P ＜0.05).결론 소혈통주사액능유효예방경골수내정술후DVT적발생,차치료비용경저렴.
Objective To observe the efficacy of shuxuetong injection to prevent postoperative deep vein thrombosis (DVT) formation in patients of tibial fractures with intramedullary nailing fixation.Methods Eightynine patients were randomly divided into study group (43 cases) and control group (46 cases) ; study group was treated by shuxuetong injection; control group were treated by low molecular weight heparin.After two weeks treatment,the incidence of DVT in lower limb was observed by B ultrasound.Results The incidence of DVT in study group was lower than that of control group [5 cases(11.6％)vs 6 cases(13.0％)].Average daily cost of anticoagulation in study group was significantly lower than that of control group.Endothelin level in study group before treatment,3 days and 14 days after operation was (30 ±9),(80 ±9),(45 ±9) ng/L; in control group it was (32 ± 9),(83 ± 9),(52 ± 9) ng/L.Conclusions Shuxuetong injection can effectively prevent the occurrence of postoperative DVT in tibial fracture patients with intramedullary nailing fixation.
