中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
12期
113-114
,共2页
TCT%高危型%HPV%宫颈癌筛查
TCT%高危型%HPV%宮頸癌篩查
TCT%고위형%HPV%궁경암사사
TCT%High risk type%HPV%Cervical cancer screening
目的：探讨液基细胞学(TCT)检查联合高危型人乳头瘤病毒(HC-Ⅱ HPV-DNA)检测在宫颈癌筛查中的临床意义。方法：2012年1月-2013年8月收集自愿接受宫颈癌筛查的妇女568例，行TCT检查，其中66例结果为不典型鳞形细胞(ASCUS)及以上，患者同时行高危型HPV检测和阴道镜检查并活检，分析两种方法对诊断宫颈病变的临床意义。结果：TCT 检查结果异常 ASCUS 30例，低度鳞状上皮内瘤变(LSIL)21例，高度鳞状上皮内瘤变(HSIL)13例，鳞状上皮细胞癌(SSC)2例。细胞学与病理诊断符合率为LSIL 73.3%(22/30)，HSIL 92.3%(12/13)，SCC 100%(2/2)。高危型 HPV 感染率51.51%(34/66)，高危型 HPV 在不同宫颈病变中的阳性率为 ASC-US 26.66%(8/30)，LSIL 66.66%(14/21)，HSIL 76.92%(10/13)，SCC 100.00%(2/2)。高危型HPV阳性率随宫颈病变程度加重而明显升高。TCT检查的敏感性81.53%，特异性91.73%；HC-Ⅱ HPV-DNA 检测的敏感性92.43%，特异性95.69%。结论：TCT 结合 HC-ⅡHPV-DNA检测增加了宫颈病变诊断的敏感性和特异性，提高了宫颈癌筛查的准确性。
目的：探討液基細胞學(TCT)檢查聯閤高危型人乳頭瘤病毒(HC-Ⅱ HPV-DNA)檢測在宮頸癌篩查中的臨床意義。方法：2012年1月-2013年8月收集自願接受宮頸癌篩查的婦女568例，行TCT檢查，其中66例結果為不典型鱗形細胞(ASCUS)及以上，患者同時行高危型HPV檢測和陰道鏡檢查併活檢，分析兩種方法對診斷宮頸病變的臨床意義。結果：TCT 檢查結果異常 ASCUS 30例，低度鱗狀上皮內瘤變(LSIL)21例，高度鱗狀上皮內瘤變(HSIL)13例，鱗狀上皮細胞癌(SSC)2例。細胞學與病理診斷符閤率為LSIL 73.3%(22/30)，HSIL 92.3%(12/13)，SCC 100%(2/2)。高危型 HPV 感染率51.51%(34/66)，高危型 HPV 在不同宮頸病變中的暘性率為 ASC-US 26.66%(8/30)，LSIL 66.66%(14/21)，HSIL 76.92%(10/13)，SCC 100.00%(2/2)。高危型HPV暘性率隨宮頸病變程度加重而明顯升高。TCT檢查的敏感性81.53%，特異性91.73%；HC-Ⅱ HPV-DNA 檢測的敏感性92.43%，特異性95.69%。結論：TCT 結閤 HC-ⅡHPV-DNA檢測增加瞭宮頸病變診斷的敏感性和特異性，提高瞭宮頸癌篩查的準確性。
목적：탐토액기세포학(TCT)검사연합고위형인유두류병독(HC-Ⅱ HPV-DNA)검측재궁경암사사중적림상의의。방법：2012년1월-2013년8월수집자원접수궁경암사사적부녀568례，행TCT검사，기중66례결과위불전형린형세포(ASCUS)급이상，환자동시행고위형HPV검측화음도경검사병활검，분석량충방법대진단궁경병변적림상의의。결과：TCT 검사결과이상 ASCUS 30례，저도린상상피내류변(LSIL)21례，고도린상상피내류변(HSIL)13례，린상상피세포암(SSC)2례。세포학여병리진단부합솔위LSIL 73.3%(22/30)，HSIL 92.3%(12/13)，SCC 100%(2/2)。고위형 HPV 감염솔51.51%(34/66)，고위형 HPV 재불동궁경병변중적양성솔위 ASC-US 26.66%(8/30)，LSIL 66.66%(14/21)，HSIL 76.92%(10/13)，SCC 100.00%(2/2)。고위형HPV양성솔수궁경병변정도가중이명현승고。TCT검사적민감성81.53%，특이성91.73%；HC-Ⅱ HPV-DNA 검측적민감성92.43%，특이성95.69%。결론：TCT 결합 HC-ⅡHPV-DNA검측증가료궁경병변진단적민감성화특이성，제고료궁경암사사적준학성。
Objective:To discuss the clinical significance of liquid based cytology(TCT) combined with high risk human papillomavirus(HC-Ⅱ HPV-DNA) detection in cervical cancer screening.Methods:568 cases of voluntary women with cervical cancer screening were selected from January 2012 to August 2013.They were given TCT examination.The results of 66 cases were atypical squamous cell(ASCUS) and above.The patients were also given high risk HPV testing and colposcopy and biopsy.The clinical significance of 2 methods in the diagnosis of cervical lesions were analyzed.Results:Abnormal TCT results showed ASCUS in 30 cases,low grade squamous intraepithelial neoplasia(LSIL) in 21 cases,high-grade squamous intraepithelial neoplasia(HSIL) in 13 cases,squamous cell carcinoma(SSC) in 2 cases.Cytological and pathological diagnosis coincidence rate showed that LSIL was 73.3%(22/30),HSIL was 92.3%(12/13),SCC was 100%(2/2).The infection rate of high-risk type HPV was 51.51%(34/66).The positive rate of high risk type HPV in different cervical lesions:ASC-US was 26.66%(8/30),LSIL was 66.66%(14/21),HSIL was 76.92%(10/13),SCC was 100%(2/2).The positive rate of high risk type HPV increased significantly with the aggravating degree of cervical lesions.The sensitivity of TCT examinations was 81.53%,the specificity was 91.73%.The sensitivity of HC-Ⅱ HPV-DNA detection was 92.43%,the specificity was 95.69%.Conclusion:TCT combined with HC-Ⅱ HPV-DNA detection increases the sensitivity and specificity of the diagnosis of cervical lesions,improve the accuracy of the cervical cancer screening.
