CAJ | 학술논문

目的：探讨舒肝解郁胶囊联合帕罗西汀治疗老年期抑郁与焦虑共病的疗效与安全性。方法：收治老年期抑郁症与焦虑共病患者64例，随机分成治疗组和对照组，治疗组用舒肝解郁胶囊联合帕罗西汀治疗，对照组单用帕罗西汀，疗程8周。采用汉密尔顿抑郁量表(HAMD)，汉密尔顿焦虑量表(HAMA)，评定疗效。治疗中需处理的不良反应采用症状量表(TESS)评定安全性。结果：两组的HAMD和HAMA评分在治疗后均逐渐降低，与治疗前相比，8周后均下降显著，具有统计学意义。在第1、2周末，比较两组间HAMD和HAMA评分，其差异无显著性，第4、6周末HAMD 和 HAMA 评分比较差异有统计学意义(P＜0.01)，治疗8周末对照组总有效率50.0%，治疗组总有效率75.0%，治疗组总有效率优于对照组(P＜0.05)。两组TESS评分在治疗后1、2、4及8差异均无统计学意义(P＞0.05)。结论：舒肝解郁胶囊联合帕罗西汀治疗老年期抑郁与焦虑共病疗效较好。
목적：탐토서간해욱효낭연합파라서정치료노년기억욱여초필공병적료효여안전성。방법：수치노년기억욱증여초필공병환자64례，수궤분성치료조화대조조，치료조용서간해욱효낭연합파라서정치료，대조조단용파라서정，료정8주。채용한밀이돈억욱량표(HAMD)，한밀이돈초필량표(HAMA)，평정료효。치료중수처리적불량반응채용증상량표(TESS)평정안전성。결과：량조적HAMD화HAMA평분재치료후균축점강저，여치료전상비，8주후균하강현저，구유통계학의의。재제1、2주말，비교량조간HAMD화HAMA평분，기차이무현저성，제4、6주말HAMD 화 HAMA 평분비교차이유통계학의의(P＜0.01)，치료8주말대조조총유효솔50.0%，치료조총유효솔75.0%，치료조총유효솔우우대조조(P＜0.05)。량조TESS평분재치료후1、2、4급8차이균무통계학의의(P＞0.05)。결론：서간해욱효낭연합파라서정치료노년기억욱여초필공병료효교호。
Objective:To discuss the efficacy and safety of Shu Gan Jie Yu capsule combined with paroxetine in the treatment of senile depression complicated with anxiety.Methods:64 patients with senile depression combined with anxiety were selected,they were randomly divided into the treatment group and the control group.The treatment group was treated with Shu Gan Jie Yu capsule combined with paroxetine;the control group was treated with paroxetine individually,the course of treatment was 8 weeks. We evaluated the curative effect with hamilton depression scale(HAMD) and hamilton anxiety scale(HAMA).We evaluated the safety with the treatment emergent symptom scale(TESS).Results:HAMD and HAMA score of two groups were decreased after treatment;compared with before treatment,it was decreased significantly after 8 weeks with statistical significance.In the first and the second weekend,we compared the HAMD and HAMA score of the two groups,the difference was not significant;the differences of HAMD and HAMA score at the fourth and sixth weekend were statistically significant(P<0.01).After 8 weeks treatment,the total effective rate was 50% in the control group;the total efficiency rate was 75% in the treatment group,the treatment group was better than that of the control group(P<0.05).TESS scores of the two groups at 1,2,4 and 8 weeks after treatment were not statistically significant(P>0.05).Conclusion:The effect of Shu Gan Jie Yu capsule combined with paroxetine in the treatment of senile depression complicated with anxiety is better.